Results 101 to 110 of about 4,715,473 (300)

Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]

, 2013
Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Jemnitz, Katalin, Monika Szabo, Katalin Jemnitz, Veres, Zsuzsa, Zsuzsa Veres, Baranyai, Zsolt, Zsolt Baranyai, Szabo, Monika, Ferenc Jakab, Jakab, Ferenc   +9 more
core   +2 more sources

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Mechanistic insights into the inhibition of NTCP by myrcludex B

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Joanne M. Donkers, Monique D. Appelman, Stan F.J. van de Graaf   +2 more
doaj   +1 more source

Relation of Gallbladder Motility to Viscosity and Composition of Gallbladder Bile in Patients with Cholesterol Gallstones [PDF]

, 2009
Background/Aims: Increased viscosity and supersaturation of cholesterol in gallbladder bile, as well as an impaired motility of the gallbladder, are considered to be important factors in the pathogenesis of cholesterol gallstones.
Straub, Gundula, Juengst, Christoph, Schneider, Berthold, del Pozo, Reginald, Juengst, Dieter, Neubrand, Michael, Spelsberg, Fritz W., Althaus, Rupert, Gruendel, Denis, Huettl, Thomas P.   +9 more
core   +1 more source

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts

Gut and Liver, 2019
Background/AimsCholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes ...
Zhu-lin Luo, Long Cheng, Tao Wang, Li-jun Tang, Fu-zhou Tian, Ke Xiang, Lin Cui   +6 more
doaj   +1 more source

Bile Acid Aspiration Associates with CLAD and Affects the Bronchial District Lipid Profile: Targeted Bile Acid Metabolomics and Lipidomics in Bronchial Washing. [PDF]

, 2016
Bile Acid Aspiration Associates with CLAD and Affects the Bronchial District Lipid Profile: Targeted Bile Acid Metabolomics and Lipidomics in Bronchial ...
Kim C, G. Di Paolo, Briganti D, H. Robbins1, F. Meloni, Sreekanth S, S. Arcasoy, Aramini B, Zhou B, L. Shah, J. Sonett, F. D'Ovidio., Raza K, Chan R   +13 more
core   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Functional, Diagnostic and Therapeutic Aspects of Bile

Clinical and Experimental Gastroenterology, 2022
Monjur Ahmed Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA, USACorrespondence: Monjur Ahmed, Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospital, 132 South 10th Street ...
Ahmed M
doaj  

A novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides

Acta Pharmaceutica Sinica B, 2017
The apical sodium--dependent bile acid transporter (ASBT) is the main transporter to promote re-absorption of bile acids from the intestinal tract into the enterohepatic circulation.
Hongtao Liu, Guoxun Pang, Jinfeng Ren, Yue Zhao, Juxian Wang   +4 more
doaj   +1 more source