Results 151 to 160 of about 4,715,473 (300)

Enterobacteria Modulate Intestinal Bile Acid Transport and Homeostasis through Apical Sodium-Dependent Bile Acid Transporter (SLC10A2) Expression

, 2020
In our study, ampicillin (AMP)-mediated decrease of enterobacteria caused increases in hepatic bile acid concentration through (at least in part) elevation of bile acid synthesis in C57BL/6N mice.
Masaaki Miyata, Yuki Takamatsu, Yasushi Yamazoe, Mayumi Hamatsu, Hiroki Yamakawa, Hideaki Kuribayashi   +5 more
core  

Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells

, 1996
Bile acids are taken up into human liver by Na+-dependent and Na+-independent transport mechanisms. In hepatocarcinogenesis, numerous liver-specific functions are lost and the uptake of organic anions is markedly reduced.
Kullak-Ublick, G. A., Paumgartner, G., Beuers, U.   +2 more
core   +1 more source

Developmental Characteristics of the Embryonic Liver Tissue and Long‐Term Culture of Primary Hepatocytes in Duck

Animal Research and One Health, EarlyView.
Liver development was investigated at different embryonic ages (EAs). Furthermore, numerous hepatocyte media were formulated and evaluated. These results could elaborate the developmental characteristics of duck liver tissue and determine the most suitable medium for the proliferation and characteristic maintenance of hepatocytes in vitro, which would ...
Jie Wei, Jing Tang, Bo Zhang, Chenchen Du, Yunsheng Zhang, Ming Xie, Zhengkui Zhou, Shuisheng Hou   +7 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Role of Organic Solute Transporter Alpha/Beta in Hepatotoxic Bile Acid Transport and Drug Interactions. [PDF]

Toxicol Sci, 2020
Beaudoin JJ, Bezençon J, Sjöstedt N, Fallon JK, Brouwer KLR.   +4 more
europepmc   +1 more source

Phylogenic and ontogenic expression of hepatocellular bile acid transport

, 1993
The phylogenic and ontogenic expression of mRNA for the Na+/bile acid cotransporter was determined by Northern analysis utilizing a full-length cDNA probe recently cloned from rat liver.
Boyer, J. L., Suchy, F., Hagenbuch, B., Ananthanarayanan, M., Stieger, B., Meier, P. J.   +5 more
core  

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter.

PLoS Pathogens
Sodium taurocholate cotransporting polypeptide (NTCP) is a hepatic transmembrane (TM) protein that functions both as a bile acid transporter and as a host receptor for hepatitis B and D viruses via the viral preS1 binding.
Kayo Matsuzawa, Toru Ekimoto, Chisa Kobayashi, Kaho Shionoya, Junki Mifune, Takeshi Morita, Junko S Takeuchi, Sam-Yong Park, Mitsunori Ikeguchi, Camille Sureau, Atsushi Kawaguchi, Koichi Watashi   +11 more
doaj   +1 more source

Computer-Aided Drug Design Unveils the Structural Requisites for Bile Acid Receptors Modulation

, 2016
Bile acids (BAs) largely control lipids and glucose metabolism interacting with nuclear and cell membrane receptors. Among these, the G-protein coupled bile acid receptor 1 (GPBAR1) is now considered a major target for the treatment of several ...
E. Novellino, S. Fiorucci, FS. Di Leva, A. Zampella, V. Limongelli   +4 more
core  

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source