Results 171 to 180 of about 234,802 (359)

Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis

Advanced Science, EarlyView.
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang, Xiaochen Gai, Yuhui Li, Zuoyu Chen, Xi Zhang, Wei Qiao, Ping Qiu, Chunyuan Du, Sufang Sheng, Jingran Hao, Yujie Zhang, Heng Fan, Xiaorong Li, Ming Liu, Jun Zhang, Zhe Pan, Yongsheng Chang   +16 more
wiley   +1 more source

Bile acids. XXXV. Metabolism of 5α-cholestan-3β-ol in the Mongolian gerbil

Journal of Lipid Research, 1972
The principal bile acid of Mongolian gerbil bile is cholic acid, although small amounts of chenodeoxycholic and lesser amounts of deoxycholic acids are identified. Muricholic acids were not found in gerbil bile.
Burton W. Noll, Rev. Lawrence B. Walsh, C. M., E.A. Doisy, Jr., William H. Elliott   +4 more
doaj  

Occurrence and Metabolism of Chenodeoxycholic Acid in the Rat. Bile Acids and Steroids. 13. [PDF]

, 1954
Sune Bergström, Jan Sjövall, Roger Bonnichsen, John Rastrup Andersen   +3 more
openalex   +1 more source

Generation of a High‐Precision Whole Liver Panorama and Cross‐Scale 3D Pathological Analysis for Hepatic Fibrosis

Advanced Science, EarlyView.
Using the MOSTtechnology and whole‐liver Nissl staining method, a multi‐structural 3D pathological panorama of liver fibrosis is obtained. The damaged sinusoids, steatotic hepatocytes, and collagen deposition are all concentrated in pericentral areas.
Xiaochuan Zhang, Weicheng Yang, Xiaoliang Li, Yanli Zhao, Zongneng Xie, Shuangqu Li, Yue Zeng, Xiaoxu Hao, Xiaohong Xin, Yu Zhang, Zixuan Feng, Hualiang Jiang, Zhaobing Gao, Xianzhen Yin   +13 more
wiley   +1 more source

Bile acids in the rat: studies in experimental occlusion of the bile duct

Journal of Lipid Research, 1966
Bile acids in the plasma, urine, and small intestine of adult male rats with occluded bile ducts have been studied using a method of high specificity for their determination. After bile duct ligation cholic acid rapidly accumulates in the plasma for 8 hr,
G.S. Boyd, M.A. Eastwood, N. Maclean
doaj  

Liquid Crystal-Based Biosensors for the Detection of Bile Acids [PDF]

, 2015
Bile acids are physiologically important metabolites, which are synthesized in liver as the end products of cholesterol metabolism and then secreted into intestine. They are amphiphilic molecules which play a critical role in the digestion and absorption
He, Sihui
core   +1 more source

The Occurrence of 7-beta-Hydroxylated Bile Acids in Human Bile. Bile Acids and Steroids. 76. [PDF]

, 1959
Jan Sjövall, Henry Danielsson, Åke Göransson, R. Sömme, Einar Stenhagen, H. Palmstierna   +5 more
openalex   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages

Cell Biochemistry and Function, Volume 40, Issue 8, Page 914-925, December 2022., 2022
Abstract ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for membrane protein targeting and activity, vesicle biogenesis, and barrier function.
Valentina E. Gómez‐Mellado, Kam S. Ho‐Mok, Vincent A. van der Mark, Nicole N. van der Wel, Anita E. Grootemaat, Arthur J. Verhoeven, Ronald P. J. Oude Elferink, Coen C. Paulusma   +7 more
wiley   +1 more source

Calcium binding by bile acids: in vitro studies using a calcium ion electrode.

Journal of Lipid Research, 1990
In this study, we compared in vitro calcium binding by the taurine and glycine conjugates of the major bile acids in human bile: cholic (CA), chenodeoxycholic (CDCA) and deoxycholic (DCA) acids, together with the cholelitholytic bile acids ...
D Gleeson, GM Murphy, RH Dowling
doaj