Results 111 to 120 of about 26,722 (309)

Immobilization Effects of Wheat Bran on Enhanced Viability of Dairy Starters under Acid and Bile Salts Stresses

, 2020
Yelena Oleinikova, Alma Amangeldi, Makpal Yelubaeva, А.Ж. АЛЫБАЕВА, Sadanov Amankeldy, Margarita Saubenova, Anna Chizhaeva, Aida Aitzhanova, Ramza Zh. Berzhanova   +8 more
openalex   +2 more sources

Gut Microbiome Dysbiosis Promotes Gallstone Formation via Bile Acid Metabolic Disorder: A Multiomics Study. [PDF]

FASEB J
Gallstone patients exhibit intestinal dysbiosis, which leads to bile acid dysregulation. Gallstone patients exhibited increased levels of bacteria with bile salt hydrolase (BSH) activity. In gallstone patients, the levels of hydrophobic bile acids (e.g., lithocholic acid) were increased, while the levels of hydrophilic bile acids (e.g ...
Huang C, Xiao W, Zhao J, Zhong R, Gao L, Ma H, Tian L, Yue P, Lin Y, He Q, Xia B, Yuan J, Yang M, Meng W.   +13 more
europepmc   +2 more sources

High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts [PDF]

, 2023
Liang Huang, Wei Wei, Xiaomei Huang, Xuejing Li, Haisha Liu, Lanlan Gui, Jinping Jiang, Linfei Wan, Xiangxiang Zhou, Jingsong Ding, Xuehua Jiang, Bikui Zhang, Ke Lan   +12 more
openalex   +1 more source

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, EarlyView.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

iMetaOmics, EarlyView.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng, Huiying Liu, Sizhe Chen, Jianhui Gu, Sisi Cai, Xiang Liu, Raphaela I. Lau, Yao Zhang, Sunjae Lee, Xiaoyan Wang, Kewei Fan, Xiaole Yin, Hein Min Tun, Renyou Gan, Haichong Wu, Qi Su   +15 more
wiley   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, EarlyView.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Profile of Serum Bile Acids in Elderly Type 2 Diabetic Patients with Various Obesity Types: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity
Mengxiao Guo,1,2 Yuejian Mao,3 Feng Xie,4 Ruirui Wang,1,5,* Lei Zhang1,5,* 1Shanghai Innovation Center of Traditional Chinese Medicine Health Service, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203,
Guo M, Mao Y, Xie F, Wang R, Zhang L
doaj  

Influence of the products of phospholipolysis of phosphatidylcholine on micellar solubilization of fatty acids in the presence of bile salts [PDF]

, 1976
A. K. Lough, Andrew H. Smith
openalex   +1 more source

Inhibition of ferroptosis by microbiota‐derived lithocholic acid underlies the intestinal radioprotection of a host defensin‐derived oligopeptide

iMeta, EarlyView.
AT9(C/G), an oligopeptide derived from human defensin 5, enriches Bifidobacterium pseudolongum and increases lithocholic acid (LCA) levels in the intestine. Reduced levels of LCA link to increased severity of ionizing radiation‐induced intestinal injury (IRIII) in both murine and clinical studies.
Xue Ouyang, Yingjuan He, Zihao Jin, Shaobo Wang, Gaomei Zhao, Xiaona Su, Jia Du, Yin Chen, Chengzhang Tan, Xin Li, Songling Han, Bin Wang, Jinghong Zhao, Jianqin Niu, Chuan Chen, Junping Wang, Cheng Wang   +16 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source