Results 131 to 140 of about 63,714 (388)

27-Hydroxycholesterol: production rates in normal human subjects

Journal of Lipid Research, 1999
We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant ...
William C. Duane, Norman B. Javitt
doaj   +1 more source

COX-2 strengthens the effects of acid and bile salts on human esophageal cells and Barrett esophageal cells [PDF]

, 2022
Shen Jiangang, Kang Nayoung, Wang Hongfang, Junda Li, Chen Li, Xuefeng Bai, Mingsong Li   +6 more
openalex   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia

Journal of Lipid Research, 2000
Patients with type IV hyperlipoproteinemia, particularly those with familial hypertriglyceridemia (FHT), have impaired absorption of bile acid, a defect that may contribute to the hypertriglyceridemia (J. Lipid Res. 1995. 36: 96–107).
William C. Duane, Linda A. Hartich, Allen E. Bartman, Samuel B. Ho   +3 more
doaj   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Adsorption of pancreatic (pro)phospholipase A2 to various physiological substrates.

Journal of Lipid Research, 1983
The adsorption of pancreatic phospholipase was studied in vitro in the presence of egg yolk lipoprotein emulsion, Intralipid emulsion, and milk fat globules.
G Nalbone, M Charbonnier-Augeire, H Lafont, R Grataroli, J L Vigne, D Lairon, C Chabert, J Leonardi, J C Hauton, R Verger   +9 more
doaj   +1 more source

Penetration enhancers in ocular drug delivery [PDF]

, 2019
There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science.
Abdulrazik, Afouna, Afouna, Agarwal, Albert, Bowling, Caretti, Chordiya, Chung, Denniston, Geerling, González de Llano, Grass, Hodges, Jackson, Jampilek, Kaur, Kefalov, Khutoryanskiy, , Lang, Lisch, Moiseev, , Montenegro, Morrison, Morrison, , Murphy, Nag, Pedersen, Quigley, Schachat, Schlote, Sebag, Smith, Steele, , Stefánsson, Sundaram, Tsai, Washington, Yanoff   +38 more
core   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Milk fat globule membrane protects Bifidobacterium longum ssp. infantis ATCC 15697 against bile stress by modifying global transcriptional responses

Journal of Dairy Science
: The milk fat globule membrane (MFGM) can protect probiotic bacteria from bile stress. However, its potential mechanism has not been reported. In this study, the viability, morphology and gene transcriptional response of Bifidobacterium longum ssp ...
Gongsheng Zhang, Mingxue He, Lihong Xiao, Yuehua Jiao, Jianchun Han, Chun Li, Michael J. Miller, Lili Zhang   +7 more
doaj   +1 more source