Results 71 to 80 of about 242,272 (375)

Focal IgG4-related autoimmune pancreatitis with distal choledochal adenocarcinoma: a rare case report

BMC Gastroenterology, 2021
Background Autoimmune pancreatitis (AIP) is a rare disease that manifests as pancreatic involvement in systemic IgG4-related disease (IgG4-RD), a special type of chronic pancreatitis caused by autoimmune abnormalities.
Han Wang, Lan Yao, Ligang Wang, Xixi Sun, Bin Huang   +4 more
doaj   +1 more source

Congenital dilatation of the common bile duct and pancreaticobiliary maljunction—clinical implications

Langenbeck's archives of surgery (Print), 2009
Clinical conditions and diagnosisCongenital dilatation of the common bile duct is a disease in which the extrahepatic bile duct, or both the extra and intrahepatic bile ducts, is dilated in various ways.
W. Kimura
semanticscholar   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

The Non‐Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF‐β‐E2F1 Axis

Advanced Science, EarlyView.
Intrahepatic microenvironment greatly impacts duration and degree of HSCs activation and development of liver fibrosis. By inhibiting TGFβ‐E2F1‐driven production of profibrogenic factors (CTGF and THBS1), hepatocyte ChREBPα monitors hepatic microenvironment and suppresses the overactivation of HSCs.
Jian Zhang, Yuee Zhao, Gauthami Pulivendala, Qing Zhang, Liangyou Rui, Jiashi Gao, Huiwen Wang, Gary Zhang, Alli Nuotio‐Antar, Xin Tong, Lei Yin   +10 more
wiley   +1 more source

Epimorphin regulates bile duct formation via effects on mitosis orientation in rat liver epithelial stem-like cells.

PLoS ONE, 2010
Understanding how hepatic precursor cells can generate differentiated bile ducts is crucial for studies on epithelial morphogenesis and for development of cell therapies for hepatobiliary diseases.
Junnian Zhou, Lei Zhao, Lipeng Qin, Jing Wang, Yali Jia, Hailei Yao, Chen Sang, Qinghua Hu, Shuangshuang Shi, Xue Nan, Wen Yue, Fengyuan Zhuang, Chun Yang, Yunfang Wang, Xuetao Pei   +14 more
doaj   +1 more source

Transplantation of patient‐specific bile duct bioengineered with chemically reprogrammed and microtopographically differentiated cells

Bioengineering & Translational Medicine, 2022
Cholangiopathy is a diverse spectrum of chronic progressive bile duct disorders with limited treatment options and dismal outcomes. Scaffold‐ and stem cell‐based tissue engineering technologies hold great promise for reconstructive surgery and tissue ...
Elina Maria Buisson, Suk‐Hee Park, Myounghoi Kim, Kyojin Kang, Sangtae Yoon, Ji Eun Lee, Young Won Kim, Nak Kyu Lee, Mi Ae Jeong, Bo‐Kyeong Kang, Seung Bum Lee, Valentina M. Factor, Daekwan Seo, Hyunsung Kim, Jaemin Jeong, Han Joon Kim, Dongho Choi   +16 more
doaj   +1 more source

NOTCH signalling – a core regulator of bile duct disease?

Disease Models & Mechanisms, 2023
ABSTRACT The Notch signalling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues.
Anabel Martinez Lyons, Luke Boulter
openaire   +3 more sources

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Effects of the administration of pentoxifylline and prednisolone on the evolution of portal fibrogenesis secondary to biliary obstruction in growing animals: immunohistochemical analysis of the expression of TGF-β and VEGF

Clinics, 2012
OBJECTIVE: During the neonatal and infancy periods, some chronic liver diseases may lead to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of organ function and severe portal hypertension necessitating hepatic ...
Wagner de Castro Andrade, Luiz Fernando Ferraz da Silva, Maria Cecilia de Mendonça Coelho, Ana Cristina Aoun Tannuri, Venancio Avancini Ferreira Alves, Uenis Tannuri   +5 more
doaj   +1 more source

Bacterial Cholangitis, Cholecystitis, or both in Dogs [PDF]

, 2016
BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions.
Allenspach, K, Day, M J, Hall, E J, Harris, B, Jahns, H, Kent, A, McAllister, H, O'Neill, E J, Procoli, F, Tamborini, A, Watson, P J   +10 more
core   +2 more sources