Results 151 to 160 of about 24,512 (278)

Abcb4 Haploinsufficiency Sensitises Mice to a Diet‐Induced PSC‐Like Hepatobiliary Phenotype With Gallstone Formation

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT ABCB4 translocates phospholipids (PL) into bile to buffer the toxicity of bile acids (BA) and free cholesterol (CHOL). While recessively inherited ABCB4 deficiency causes childhood Progressive Familial Intrahepatic Cholestasis type 3, haploinsufficiency has been linked to adult‐onset hepatobiliary diseases.
Eric L. Bell, Youhwa Jo, Jennifer K. Truong, Nathan O. Fuller, John P. Miller, Alastair S. Garfield, Robert O. Hughes   +6 more
wiley   +1 more source

Association Between Pruritus and Healthcare Utilization and Costs Among Individuals With Primary Biliary Cholangitis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background and Aims Pruritus is a debilitating, under‐prioritized symptom of primary biliary cholangitis (PBC). This study assessed its impact on healthcare resource utilization (HCRU) and costs in the US. Methods A retrospective cohort study of individuals with PBC was conducted using Komodo's claims and laboratory data between September 1 ...
Robert G. Gish, Michel H. Mendler, Edward A. Mena, Chong Kim, C. Fiorella Murillo Perez, Yi Pan, Lauren A. Do, Mihail Samnaliev, Maria Agapova   +8 more
wiley   +1 more source

Transcription factors SOX4 and SOX9 cooperatively control development of intrahepatic bile ducts

, 2015
In developing liver, cholangiocytes derive from the hepatoblasts and organize to form the bile ducts. Earlier work has shown that SOX9 is transiently required for bile duct development, raising the question of the potential involvement of other SOX ...
Poncy, Alexis
core  

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Intrahepatic cholestasis in chronic liver disease

, 1996
Cholestasis syndromes are characterized by a reflux of compounds usually excreted with bile. ATP dependent carriers and cytoskeleton proteins guarantee physiological bile flux.
Pezzoli A., Fabbri C., Marchetto S., Roda E., Fusaroli P., Azzaroli F., Mazzella G., Jaboli F.   +7 more
core  

Imaging diagnosis of Caroli-like disease with concurrent extrahepatic biliary obstruction in a young small-breed dog: case report. [PDF]

Front Vet Sci
Park J, Cho SY, Kiupel M, Lee K, Yoon H.
europepmc   +1 more source

Hepatic Arterial Infusion Chemotherapy plus either Toripalimab or Sorafenib as First‐line Therapy for Locally Advanced Hepatocellular Carcinoma: A Non‐comparative, Randomized Phase 2 Trial

MedComm, Volume 7, Issue 6, June 2026.
This phase II study explored the efficacy and safety of HAIC plus toripalimab in locally advanced HCC. The primary endpoint was the PFS rate at 6 months. The 6‐month PFS rate was 63.9% in the TorHAIC group and 61.1% in the SoraHAIC group. Treatment with the TorHAIC regimen resulted in a median OS of 20.9 months and a median PFS of 9.1 months.
Zhicheng Lai, Aojie Ge, Hanyue Ouyang, Zichao Wu, Yexing Huang, Qijiong Li, Li Xu, Binkui Li, Minshan Chen, Dongsheng Wen, Anna Kan, Ming Shi, Minke He   +12 more
wiley   +1 more source

Spectrum of Biliary and Nonbiliary Neoplasms Growing and Spreading Within the Lumen of the Bile Ducts. [PDF]

Cancers (Basel)
Nakanuma Y, Sato Y, Kakuda Y, Oishi T.
europepmc   +1 more source

The Dynamic Evolution of Lipid Profiles Following Transjugular Intrahepatic Portosystemic Shunt in Patients With Liver Cirrhosis

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 150-159, June 2026.
Cirrhosis is frequently accompanied by varying degrees of lipid profile abnormalities. This study confirms that these profiles are differentially affected by disease etiology and progressively worsen—with significant reductions in TC, HDL‐C, and LDL‐C—as liver disease severity increases. TIPS improves lipid profiles, particularly by increasing HDL‐C in
Jiamin Xu, Qinnian Li, Lagan Kumar Manandhar, Bilian Zhu, Chenrui Zhang, Weimin Bao, Yingmei Tang   +6 more
wiley   +1 more source

Case Report: Primary squamous cell carcinoma of the pancreatic segment of the extrahepatic bile duct: a rare tumor easily misdiagnosed as pancreatic malignancy. [PDF]

Front Oncol
Xu T, Meng X, Gou X, Wang X, Luo S, Chen Y.   +5 more
europepmc   +1 more source