REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression [PDF]
arXiv, 2023 Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments.
arxiv
Isolation and primary cultures of human intrahepatic bile ductular epithelium [PDF]
, 1988 A technique for the isolation of human intrahepatic bile ductular epithelium, and the establishment of primary cultures using a serum- and growth-factor-supplemented medium combined with a connective tissue substrata is described.
A. E. Sirica +24 more
core +1 more source
Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury [PDF]
arXiv, 2023 During liver transplantation, ischemia-reperfusion injury (IRI) is inevitable and decreases the overall success of the surgery. While guidelines exist, there is no reliable way to quantitatively assess the degree of IRI present in the liver. Our recent study has shown a correlation between the bile-to-plasma ratio of FDA-approved sodium fluorescein (SF)
arxiv
A case of distal extrahepatic cholangiocarcinoma with two positive resection margins [PDF]
, 2016 Cholangiocarcinoma is an uncommon primary malignancy of the biliary tract that is challenging to diagnose and treat effectively due to its relatively silent and late clinical presentation.
Andersen +42 more
core +2 more sources
CONGENITAL MALFORMATION OF THE LIVER IN A NEWBORN (CLINICAL CASE)
Мать и дитя в Кузбассе, 2020 Congenital hyperplasia of the intrahepatic bile ducts refers to early fetopathy. It represents a «bizarre» proliferation of bile ducts in the portal tract with excessive development of connective tissue.
Наталья Анатольевна Батина +6 more
doaj
Microbiome-derived bile acids contribute to elevated antigenic response and bone erosion in rheumatoid arthritis [PDF]
arXiv, 2023 Rheumatoid arthritis (RA) is a chronic, disabling and incurable autoimmune disease. It has been widely recognized that gut microbial dysbiosis is an important contributor to the pathogenesis of RA, although distinct alterations in microbiota have been associated with this disease.
arxiv
Multiple Biliary Hamartomas, The ‘‘Von Meyenburg Complexes’’
Annals of Hepatology, 2017 Multiple biliary hamartomas are rare benign malformations of the intrahepatic bile ducts first described by von Meyenburg in 1918. They originate from embryonic bile ducts that fail to involute. These are generally asymptomatic and usually encountered as
Joel O. Jáquez-Quintana +2 more
doaj
Liver Transplantation for Alagille's Syndrome [PDF]
, 1993 Twenty-three children with Alagille's syndrome and end-stage liver disease underwent liver transplantation with cyclosporine and low-dose steroid immunosuppression. Two to 9 years (mean, 4.4 years) after surgery, 13 (57%) of the children were still alive,
Reyes, J +5 more
core +1 more source
Biliary tract complications in human orthotopic liver transplantation [PDF]
, 1987 The results of 393 consecutive orthotopic liver transplants in 313 patients were reviewed to determine the incidence of primary biliary tract complications.
Esquivel, CO +6 more
core +1 more source
, 2017 Liver fluke infections occur in people worldwide. In some low-income regions, a combination of ecological, agricultural, and culinary factors leads to a very high prevalence of infection but, in higher-income regions, infections are uncommon.
Harrington, David +2 more
core +1 more source