Results 81 to 90 of about 22,949 (221)

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, EarlyView.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source

Phase II Trial of Nivolumab in Advanced Solid Tumors Based on Genomic Profiling: BELIEVE Trial (NCCH1901) Subcohort

Cancer Science, EarlyView.
Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai, Kuniko Sunami, Tatsunori Shimoi, Satoshi Nishiwaki, Ichiro Kinoshita, Tetsuhiro Yoshinami, Chigusa Morizane, Yusuke Sato, Toshio Kubo, Mamoru Ito, Hiroshi Nishihara, Toru Mukohara, Hidekazu Shirota, Ryo Ko, Taro Shibata, Manabu Muto, Noboru Yamamoto   +16 more
wiley   +1 more source

GEVIS: A Workflow‐Driven Visual Analytics Approach to Differential Gene Expression Analysis

Computer Graphics Forum, EarlyView.
Abstract Differential gene expression (DGE) analysis is one of the most widely used techniques for investigating RNA‐seq data and supports numerous medical and biological applications, including biomarker identification for diagnosis and prognosis, as well as the evaluation of medical treatments.
G. Blasilli, F. Fortunato, C. Santaroni, G. Fiscon, G. Santucci   +4 more
wiley   +1 more source

Extended Double Plasma Molecular Adsorption Sessions and Bilirubin Clearance: A Case Report

Hemodialysis International, EarlyView.
ABSTRACT Background The double plasma molecular adsorption system is an artificial‐liver treatment model combining the use of ion exchange resins and neutral microporous resins to remove toxins such as inflammatory cytokines without consuming large amounts of plasma and albumin. Given the relatively expensive consumables needed for Bilirubin adsorption,
Hui Ye, Yi Long Hao, Hai Nan Yang, Wei Fang Yuan, Kai Liang Xu, Xiao Xiao Li, Ming Lei, Yu Xia Sun   +7 more
wiley   +1 more source

Prognostic Value of PALBI in Patients With Hepatocellular Carcinoma and Concurrent Chronic Kidney Disease: A Nomogram Development

Hepatology Research, EarlyView.
Patients with hepatocellular carcinoma (HCC) as well as chronic kidney disease (CKD) are high‐risk individuals, making it challenging to accurately predict their survival. We found that the PALBI grade model when combined with other patient's clinical and tumor‐related factors, forms a new and highly accurate prediction tool to estimate their ...
Jihye Lim, Seok–Hwan Kim, Myeong Jun Song   +2 more
wiley   +1 more source

Congenital Absence of the Intrahepatic Bile Ducts [PDF]

Archives of Disease in Childhood, 1958
L, HAAS, R H, DOBBS
openaire   +2 more sources

Anti‐Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric‐Onset Primary Sclerosing Cholangitis

Hepatology Research, EarlyView.
Levels of anti‐integrin αvβ6 antibodies were significantly higher in pediatric‐onset primary sclerosing cholangitis (PSC) than in autoimmune hepatitis (AIH) and may reflect disease activity. These antibodies may serve as a novel biomarker for distinguishing PSC from AIH and for monitoring disease progression.
Yukako Maeda, Shuichiro Umetsu, Eitaro Hiejima, Mitsuyoshi Suzuki, Itaru Iwama, Takeshi Kimura, Sonoko Kondo, Ayano Inui, Hiroki Kondou, Tatsuya Okamoto, Takashi Ito, Hiroyuki Shirahase, Kazushi Izawa, Takahiro Yasumi, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno, Junko Takita   +17 more
wiley   +1 more source

Baseline and Longitudinal Liver Stiffness Measurement Predict Outcomes in Primary Biliary Cholangitis: A Multicenter Study

Hepatology Research, EarlyView.
We conducted a multicenter cohort study analyzed 454 Japanese PBC patients. Baseline LSM ≥ 8.0 kPa was independently associated with adverse outcomes. ΔLSM/year ≥ 2.1 kPa was independently associated with adverse outcomes. ABSTRACT Background & Aims Liver stiffness measurement (LSM) using vibration‐controlled transient elastography (VCTE) is a ...
Yuki Yamashita, Takefumi Kimura, Kaede Fujita, Taiki Okumura, Takanobu Iwadare, Hiroyuki Kobayashi, Shun‐ichi Wakabayashi, Tomoo Yamazaki, Satoru Joshita, Takeji Umemura, Masanori Abe, Akinobu Takaki, Kazumichi Abe, Masaaki Takamura, Tadashi Namisaki, Yuki Kugiyama, Atsumasa Komori, Atsushi Tanaka   +17 more
wiley   +1 more source

The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study

Discover Oncology
Background Platelet indices are non-invasive biomarkers used to assess disease status. Observational studies have shown that platelet indices are related to liver cancer. However, the specific relationship between the two is still inconclusive.
Xin He, Yuzhe Zhang, Zhengsheng Yi, Xiaohui Zhao, Yusheng Shi, Shengni Hua   +5 more
doaj   +1 more source

Laser Lithotrpsy of Large Choledochal Stones

Diagnostic and Interventional Endoscopy
Objective: The purpose of laserlithotripsy accompanied bycholangioscopy is to break the Stones into smaller pieces that form in the bile ducts and cannot be removed by conventional methods.This procedure is performed to relieve obstruction of the bile ...
Ali Erkan Duman, Emrah Gülşen
doaj   +1 more source