Results 51 to 60 of about 40,709 (257)

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Interactions of cationic bile salt derivatives with the ileal bile salt transport system.

Journal of Lipid Research, 1975
Previous structure-activity studies of the active ileal bile salt transport system have demonstrated that a single negative charge on the side chain is essential for active transport. Furthermore, mutual inhibition studies between different pairs of bile
A Firpi, J T Walker, L Lack
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Functional significance of interaction of H-FABP with sulfated and nonsulfated taurine-conjugated bile salts in rat liver.

Journal of Lipid Research, 1995
To identify the cytosolic proteins of rat hepatocytes involved in transcellular transport of sulfated and taurine-conjugated bile salts in comparison with only taurine-conjugated bile salts, photoaffinity labeling studies were performed with [3H]-7,7 ...
A Dietrich, W Dieminger, K Fuchte, G H Stoll, E Schlitz, W Gerok, G Kurz   +6 more
doaj   +1 more source

Cholesterol Solubilization by Solutions of Bile Salts and Bile Salts Plus Lecithin

Experimental Biology and Medicine, 1968
SummaryModel synthetic solutions were used to study cholesterol solubilization by the 6 conjugated bile salts found in human bile individually and as a mixture, and by lecithin in combination with bile salts. In the range of concentrations found in bile, bile salts alone solubilized only about one third as much cholesterol as might be found in ...
D H, Neiderhiser, H P, Roth
openaire   +2 more sources

Structural basis for the bile salt-mediated activation and translocation of the type III secretion system 2 in Vibrio Parahaemolyticus

CyTA - Journal of Food
Type III secretion system 2 (T3SS2) is a major virulence determinant of Vibrio parahaemolyticus and can be induced by intestinal bile salts. However, the potential structural interactions between bile salts and T3SS2 proteins remain unclear.
Gui Fu, Aoning Li, Lei Zhu, Huan Li, Zhaohuan Zhang, Yong Zhao, Jing Liu   +6 more
doaj   +1 more source

Response to Bile Salts in Clinical Strains of Acinetobacter baumannii Lacking the AdeABC Efflux Pump: Virulence Associated with Quorum Sensing

Frontiers in Cellular and Infection Microbiology, 2017
Introduction:Acinetobacter baumannii is an opportunistic nosocomial pathogen associated with multiple infections. This pathogen usually colonizes (first stage of microbial infection) host tissues that are in contact with the external environment.
Maria López, Maria López, Lucia Blasco, Eva Gato, Eva Gato, Astrid Perez, Astrid Perez, Laura Fernández-Garcia, Laura Fernández-Garcia, Luis Martínez-Martinez, Luis Martínez-Martinez, Luis Martínez-Martinez, Felipe Fernández-Cuenca, Felipe Fernández-Cuenca, Felipe Fernández-Cuenca, Jesús Rodríguez-Baño, Jesús Rodríguez-Baño, Jesús Rodríguez-Baño, Alvaro Pascual, Alvaro Pascual, Alvaro Pascual, German Bou, German Bou, Maria Tomás, Maria Tomás   +24 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Cholecysto-appendicostomy as partial internal biliary drainage in Progressive Familial Intrahepatic Cholestasis Type 1: A case report and review of literature

Journal of Pediatric Surgery Case Reports, 2016
Intractable pruritus secondary to bile salts retention in Progressive Familial Intrahepatic Cholestasis (PFIC) can be relieved surgically by diverting bile drainage from ileum to reduce bile salts reabsorption into entero-hepatic circulation.
Yee Ian Yik, Mohd Yusran Othman, Ruey Terng Ng, Way Seah Lee   +3 more
doaj   +1 more source