Results 51 to 60 of about 87,175 (303)

Substrate Inhibition of 5β-Δ4-3-Ketosteroid Dehydrogenase in Sphingobium sp. Strain Chol11 Acts as Circuit Breaker During Growth With Toxic Bile Salts

Frontiers in Microbiology, 2021
In contrast to many steroid hormones and cholesterol, mammalian bile salts are 5β-steroids, which leads to a bent structure of the steroid core. Bile salts are surface-active steroids excreted into the environment in large amounts, where they are subject
Franziska M. Feller, Gina Marke, Steffen L. Drees, Lars Wöhlbrand, Ralf Rabus, Bodo Philipp, Bodo Philipp   +6 more
doaj   +1 more source

Ligand entry in human ileal bile acid-binding protein is mediated by histidine protonation [PDF]

, 2019
Human ileal bile acid-binding protein (hI-BABP) has a key role in the intracellular transport of bile salts. To explore the role of histidine protonation in the binding process, the pH-dependence of bile salt binding and internal dynamics in hI-BABP was ...
Egyed, Orsolya, Horváth, Gergő, Kardos, József, Kovács, Mihály, Micsonai, András, Tang, Changguo, Toke, Orsolya   +6 more
core   +4 more sources

Bile salt evolution

Journal of Lipid Research, 1967
Viewed against the background of known or supposed biosynthetic pathways for cholic and chenodeoxycholic acids in man and laboratory animals, the chemical nature of bile salts in more primitive animals clearly indicates that evolution from C(27), 5alpha-alcohol sulfates to C(24), 5beta-acids has taken place.
openaire   +3 more sources

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Binding of bile salts to pancreatic colipase and lipase

Journal of Lipid Research, 1975
The binding of conjugated bile salts to pancreatic colipase and lipase has been studied by equilibrium dialysis and gel filtration. The results indicate that at physiological ionic strength and pH, conjugated bile salts bind as micelles to colipase: 12 ...
B. Borgström, J. Donnér
doaj   +1 more source

Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs [PDF]

, 2017
Fungi and bacteria can persist in the human gall bladder. Previous studies have shown that bile protects Candida albicans in this cryptic host niche from antifungals, providing a reservoir for intestinal re-colonization after discontinuation of ...
Brock, Matthias, Hsieh, Shih-Hung
core   +2 more sources

Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy

Advanced Functional Materials, EarlyView.
In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova, Ivan V. Zelepukin, Konstantin G. Shevchenko, Gleb V. Tikhonowski, Lyubov V. Gorelik, Anton A. Popov, Anna S. Sogomonyan, Alina Yu. Kapitannikova, Ivan S. Kazantsev, Dmitry V. Dyubo, Daria A. Panova, Daniil I. Tselikov, Anton A. Minnekhanov, Aziz B. Mirkasymov, Georgy A. Ermolaev, Alexander V. Syuy, Gleb I. Tselikov, Aleksey V. Arsenin, Andrei V. Kabashin, Kostya S. Novoselov, Sergey M. Deyev, Valentyn S. Volkov   +21 more
wiley   +1 more source

Importance of Bile Composition for Diagnosis of Biliary Obstructions

Molecules, 2021
Determination of the cause of a biliary obstruction is often inconclusive from serum analysis alone without further clinical tests. To this end, serum markers as well as the composition of bile of 74 patients with biliary obstructions were determined to ...
Łukasz Krupa, Robert Staroń, Dorota Dulko, Natalia Łozińska, Alan R. Mackie, Neil M. Rigby, Adam Macierzanka, Aleksandra Markiewicz, Christian Jungnickel   +8 more
doaj   +1 more source

Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis [PDF]

, 2006
Background. Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease.
Abdel-Wahab M, Abu Farsakh NA, Akdamar K, Bechi P, Benedikta Zündt, Burkhard Göke, Cabrol J, Cabrol J, Caldwell MT, Dieter Jüngst, Dixon MF, Dooley CP, Emmanouilidis A, Fahlke J, Fritz W. Spelsberg, Gad Elhak N, Gnatiuk NG, Hubens A, Hyvarinen H, Ihamaki T, Joachim Diebold, Johnsen R, Kellosalo J, Koch HK, Ladas SD, Lasse Kolligs, Lorusso D, Lorusso D, Lujan-Mompean JA, Mackie CR, Manifold DK, Niemela S, Panos Stathopoulos, Ritchie, Robles-Campos R, Svensson JO, Ure BM, Watson RG, Yavorski CC   +38 more
core   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source