Results 41 to 50 of about 645 (124)

Small molecule antagonism of oxysterol‐induced Epstein–Barr virus induced gene 2 (EBI2) activation

FEBS Open Bio, Volume 3, Issue 1, Page 156-160, January 01, 2013., 2013
The Epstein–Barr virus induced gene 2 (EBI2) was recently identified as the first oxysterol‐activated 7TM receptor. EBI2 is essential for B cell trafficking within lymphoid tissues and thus the humoral immune response in general. Here we characterize the antagonism of the non‐peptide molecule GSK682753A, which blocks oxysterol‐induced G‐protein ...
Tau Benned-Jensen, Christian M. Madsen, Kristine N. Arfelt, Christian Smethurst, Andy Blanchard, Robert Jepras, Mette M. Rosenkilde   +6 more
wiley   +1 more source

Epstein‐Barr Virus in Systemic Autoimmune Diseases

Journal of Immunology Research, Volume 2013, Issue 1, 2013., 2013
Systemic autoimmune diseases (SADs) are a group of connective tissue diseases with diverse, yet overlapping, symptoms and autoantibody development. The etiology behind SADs is not fully elucidated, but a number of genetic and environmental factors are known to influence the incidence of SADs.
Anette Holck Draborg, Karen Duus, Gunnar Houen, Guixiu Shi   +3 more
wiley   +1 more source

Structural Diversity in Conserved Regions Like the DRY‐Motif among Viral 7TM Receptors—A Consequence of Evolutionary Pressure?

Advances in Virology, Volume 2012, Issue 1, 2012., 2012
Several herpes‐ and poxviruses have captured chemokine receptors from their hosts and modified these to their own benefit. The human and viral chemokine receptors belong to class A 7 transmembrane (TM) receptors which are characterized by several structural motifs like the DRY‐motif in TM3 and the C‐terminal tail. In the DRY‐motif, the arginine residue
Ann-Sofie Mølleskov Jensen, Alexander Hovard Sparre-Ulrich, Nicholas Davis-Poynter, Mette Marie Rosenkilde, Rika Draenert   +4 more
wiley   +1 more source

Epstein-Barr Virus and Systemic Autoimmune Diseases [PDF]

, 2021
Epstein-Barr Virus (EBV) is an extremely successful human herpes virus, which infects essentially all human beings at some time during their life span. EBV infection and the associated immune response results in production of antibodies (seroconversion),
Houen, Gunnar, Trier, Nicole Hartwig
core   +1 more source

Model Systems of Gammaherpesvirus Infection, Immunity, and Disease

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT Epstein‐Barr virus (EBV) and Kaposi's sarcoma‐associated herpesvirus (KSHV) are oncogenic human gammaherpesviruses (GHVs) associated with a broad spectrum of malignancies and chronic diseases. However, direct studies of these viruses in humans are limited by ethical constraints, technical challenges, and their strict species specificity.
Arundhati Gupta, Renfeng Li, Kathy Shair, Shou‐Jiang Gao   +3 more
wiley   +1 more source

Insight into structural properties of viral G protein‐coupled receptors and their role in the viral infection: IUPHAR Review 41

British Journal of Pharmacology, Volume 182, Issue 1, Page 26-51, January 2025.
G protein‐coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such as viral spreading and immune evasion.
Naotaka Tsutsumi, Dagmar Fæster Kildedal, Olivia Kramer Hansen, Qianqian Kong, Dominique Schols, Tom Van Loy, Mette Marie Rosenkilde   +6 more
wiley   +1 more source

Epigenetic regulation of Epstein–Barr virus: From bench to bedside

Clinical and Translational Discovery, Volume 4, Issue 5, October 2024.
EBV acts as an epigenetic driver in carcinogenesis and mainly refers to DNA methylation, RNA methylation, histone modification, chromatin accessibility, and the three‐dimensional (3D) genome structure. Abstract Background Epstein–Barr virus (EBV) is a double‐stranded DNA herpesvirus and establishes life‐long infection in 95% of the world's populations.
Xiao Gao, Hao‐Xu Yang, Shu Cheng, Hua‐Man Cai, Jie Xiong, Wei‐Li Zhao   +5 more
wiley   +1 more source

Development of a Broad-Spectrum Antiviral Agent with Activity Against Herpesvirus Replication and Gene Expression [PDF]

, 2013
Purpose: To evaluate the broad-spectrum antiviral activity of peptide H9 (H9) in vitro in order to gain insight into its underlying molecular mechanisms.Method: Antiviral activity against Herpes simplex virus type 1 (HSV-1) was determined using thiazolyl
Li, SY, Li, XY, Liu, HA, Mo, XM, Shi, WJ, Sun, HX, Zhang, G   +6 more
core   +2 more sources

The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer

Cancer Medicine, Volume 13, Issue 17, September 2024.
Abstract Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorganisms promptly, allowing them to persist by evading immune defenses.
Si Chen, Caihong Yao, Na Tian, Chunying Zhang, Yuemei Chen, Xuting Wang, Yue Jiang, Tonghao Zhang, Tingting Zeng, Yali Song   +9 more
wiley   +1 more source

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells [PDF]

, 2018
Cell-mediated immunity plays a key role in host control of viral infection. This is exemplified by life-threatening reactivations of e.g. herpesviruses in individuals with impaired T-cell and/or iNKT cell responses.
Adema, Gosse J, Bull, Christian, Comvalius, Anouskha, Dickson, Kathryn, Gram , Anna M, Griffioen, Marieke, Heemskerk, Mirjam HM, Hoeben, Rob C, Hutt-Fletcher, Lindsay M, Lebbink, Robert Jan, Lindenbergh, Marthe FS, Oosenbrug, Timo, Ressing, Maaike E, Tscharke, David, Vrolijk, Hans, Wiegant, Joop, Wiertz, J, Wolterbeek, Ron   +17 more
core   +1 more source