Results 141 to 150 of about 77,911 (193)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

Zero‐Shot Self‐Supervised Learning of Single Breath‐Hold Magnetic Resonance Cholangiopancreatography (MRCP) Reconstruction

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1666-1681, October 2026.
ABSTRACT Purpose To investigate the feasibility of zero‐shot self‐supervised learning reconstruction for reducing breath‐hold times in magnetic resonance cholangiopancreatography (MRCP). Methods Breath‐hold MRCP was acquired from 11 healthy volunteers on 3T scanners using an incoherent k‐space sampling pattern, leading to a 14‐s acquisition time and an
Jinho Kim, Marcel Dominik Nickel, Florian Knoll   +2 more
wiley   +1 more source

Issue Information

DEN Open, Volume 7, Issue 1, April 2027.
wiley   +1 more source

Duodenal stricture and portal gas accumulation secondary to ulcerative, fibronecrotising duodenitis in a foal

Equine Veterinary Education, Volume 38, Issue 10, Page e665-e670, October 2026.
Summary Gastroduodenal ulcer disease with secondary stricture formation of the proximal duodenum and portal gas accumulation is described in a neonatal foal. Conventional diagnostics were performed to reach a diagnosis, including gastroscopy, ultrasonography and positive contrast radiography. In addition, a post‐mortem CT was acquired with the contrast
R. F. Dash, G. Manso‐Diaz, A. Suarez‐Bonnet, M. Hewetson   +3 more
wiley   +1 more source

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice is limited. Therefore, validation of the diagnostic value of NGS
Antonia Gillmeister, Julia Husman, Renate Schmelz, Stefan Brückner, Jochen Hampe, Daniela Aust, Sebastian Zeissig   +6 more
wiley   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1419-1427, September 2026.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Pylorus‐Preserving Gastrectomy for Gastric Cancer: Current Evidence and Future Directions

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1388-1403, September 2026.
This review aims to outline the current evidence and future directions of PPG, focusing on the feasibility of extending its application beyond its traditional indications. ABSTRACT Pylorus‐preserving gastrectomy (PPG) is a function‐preserving surgery for clinically T1N0M0 (cT1N0M0) early gastric cancer (EGC) located in the middle third of the stomach ...
Sa‐Hong Kim, Hyuk‐Joon Lee
wiley   +1 more source

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3037-3048, September 2026.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, Volume 4, Issue 3, September 2026.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Intestinal Metaplasia of the Distal Esophagus in a Patient With Untreated Achalasia—An Unusual Case and Review of Literature

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Barrett's esophagus (BE) and achalasia are distinct esophageal disorders with opposing pathophysiologic mechanisms, making their coexistence exceedingly rare. We describe a 51‐year‐old woman who presented with progressive dysphagia, postprandial vomiting, and significant weight loss over 8 months.
Rohan Karkra, Mahinaz Mohsen, Salil Chowdhury, Kaveh Hajifathalian, Ahmed Al‐Khazraji   +4 more
wiley   +1 more source