Results 201 to 210 of about 575,936 (265)

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Association Between Cumulative Chemotherapy Exposure and Survival Outcomes in Advanced Biliary Tract Cancer. [PDF]

Cancers (Basel)
Nguyen VK, Kosaka H, Matsui K, Matsushima H, Yamamoto H, Kiguchi G, Ohigashi T, Lai TT, Duong HH, Inoue K, Takada M, Kato H, Yoshii K, Ito T, Ikeura T, Naganuma M, Kaibori M.   +16 more
europepmc   +1 more source

Osteotomies around the knee are associated with low short‐term adverse event and reoperation rates: A 25‐year national Hospital Episode Statistics analysis in England

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Osteotomy around the knee (OAK) is an established joint‐preserving procedure. We sought to use large‐scale registry data to examine the short‐term reoperation and adverse outcome rates after OAK. Methods Data on high tibial osteotomy (HTO) and distal femoral osteotomy (DFO) patients were extracted from UK National Health Service ...
Conor Hennessy, Bilal Rayes, Benjamin G. Faber, James Murray, Simon G. F. Abram   +4 more
wiley   +1 more source

Antiangiogenic therapy for advanced biliary tract cancers: promising or illusory? [PDF]

J Gastrointest Oncol
Colle R, Malka D.
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

The interplay between bile acid metabolism and gut microbiome in biliary tract cancers. [PDF]

Front Microbiomes
Ike I, Teymouri F, Crook C, Guzman S, Hazeltine M, Castillo D, Li D, Brar G.   +7 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Durvalumab Plus Chemotherapy for Advanced Biliary Tract Cancer: A Post Hoc Analysis of the TOPAZ-1 Randomized Clinical Trial.

JAMA Oncol
Oh DY, He AR, Qin S, Chen LT, Okusaka T, Griffin R, Wang J, Xynos I, Vogel A, Valle JW.   +9 more
europepmc   +1 more source

Early-life body size and risk of developing biliary tract cancers. [PDF]

Cancer
Bhattacharjee PS, Baker JL, Pfeiffer RM, Jackson SS, Aarestrup J, Koshiol J.   +5 more
europepmc   +1 more source