Results 61 to 70 of about 159,964 (350)

Safety and Efficacy of Allogeneic Natural Killer Cells in Combination with Pembrolizumab in Patients with Chemotherapy-Refractory Biliary Tract Cancer: A Multicenter Open-Label Phase 1/2a Trial

Cancers, 2022
Simple Summary Since there is no effective subsequent-line therapy for patients with cisplatin/gemcitabine-refractory advanced biliary tract cancer, there is an urgent need for new treatment options.
Galam Leem, S. Jang, Jae-Hee Cho, J. Jo, H. Lee, M. Chung, J. Park, Seungmin Bang, D. Yoo, H. Cheon, Jae-Eun Kim, Kyeong-Pill Lim, I. Jung, J. Im, Y. Chung, Seung Woo Park   +15 more
semanticscholar   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers

Nature Communications, 2023
In biliary tract cancer HER2 alterations correlate with poor prognosis. Here, the authors present the results of a phase II clinical trial reporting the efficacy and safety of the tyrosine kinase inhibitor neratinib in patients with HER2-mutation ...
James J. Harding, Sarina A. Piha-Paul, Ronak H. Shah, Jessica J. Murphy, James M. Cleary, Geoffrey I. Shapiro, David I. Quinn, Irene Braña, Victor Moreno, Mitesh Borad, Sherene Loi, Iben Spanggaard, Haeseong Park, James M. Ford, Mónica Arnedos, Salomon M. Stemmer, Christelle de la Fouchardiere, Christos Fountzilas, Jie Zhang, Daniel DiPrimeo, Casey Savin, S. Duygu Selcuklu, Michael F. Berger, Lisa D. Eli, Funda Meric-Bernstam, Komal Jhaveri, David B. Solit, Ghassan K. Abou-Alfa   +27 more
doaj   +1 more source

Multitasking Smart Intestinal Capsule Robot: A Cutting‐Edge Platform for Sampling, Diagnosis, and Therapy

Advanced Robotics Research, EarlyView.
Gut microbiota and biomarkers are linked to diseases like neurological disorders and metabolic syndromes. Ingestible capsule robots enable minimally invasive gut health assessment. This article proposes a promising direction for the advancement of capsule robots, integrating in situ sampling, real‐time diagnostics, and personalized therapy.
Xizong Chen, Libing Huang, Lei Ren, Miao Wang   +3 more
wiley   +1 more source

Mutational signatures in 175 Chinese gastric cancer patients

BMC Cancer
Background Gastric cancer (GC), a molecularly heterogeneous disease, is the third leading cause of cancer death worldwide. The majority of GC cases worldwide occur in East Asia, predominantly China.
Fatao Liu, Nan Hu, Kewei Jiang, Huaitian Liu, Mingyi Wang, Ying Hu, Tongwu Zhang, Ho-Hsiang Wu, Howard Yang, Hao Weng, Ping Dong, Carol Giffen, Bin Zhu, Maxwell P. Lee, Christian C. Abnet, Philip R. Taylor, Yun Liu, Yingbin Liu, Alisa M. Goldstein   +18 more
doaj   +1 more source

Hospital Surgical Volume and 3-Year Mortality in Severe Prognosis Cancers: A Population-Based Study Using Cancer Registry Data

Journal of Epidemiology, 2021
Background: The impact of hospital surgical volume on long-term mortality has not been well assessed in Japan, especially for esophageal, biliary tract, and pancreatic cancer, although these three cancers need a high level of medical-technical skill. The
Yukari Taniyama, Takahiro Tabuchi, Yuko Ohno, Toshitaka Morishima, Sumiyo Okawa, Shihoko Koyama, Isao Miyashiro   +6 more
doaj   +1 more source

Genomic alterations in biliary tract cancer predict prognosis and immunotherapy outcomes

Journal for ImmunoTherapy of Cancer, 2021
Background Recently, immunotherapy with immune checkpoint inhibitors (ICIs) has shown promising efficacy in biliary tract cancer (BTC), which includes gallbladder cancer (GBC) and cholangiocarcinoma (CHOL).
Xiaofeng Chen, Deqiang Wang, Jing Liu, J. Qiu, Jun Zhou, J. Ying, Yan Shi, Zhaoxia Wang, H. Lou, J. Cui, Jingdong Zhang, Yunpeng Liu, Fengjiao Zhao, Lan-hong Pan, Jianyi Zhao, Dongqin Zhu, Shiqing Chen, Xia Li, Xue Li, Liuqing Zhu, Y. Shao, Y. Shu   +21 more
semanticscholar   +1 more source

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Biliary tract cancers: SEOM clinical guidelines [PDF]

Clinical and Translational Oncology, 2015
Biliary tract cancer (BTC) is an uncommon and highly fatal malignancy. It is composed of three main different entities; Gall bladder carcinoma (GBC), intrahepatic cholangiocarcinoma (iCC) and extrahepatic cholangiocarcinoma (eCC) sharing different genetic, risk factors and clinical presentation. Multidetector-row computed tomography (MDCT) and magnetic
Benavides, M., Antón, A., Gallego, J., Gómez, M. A., Jiménez-Gordo, A., La Casta, A., Laquente, B., Macarulla, T., Rodríguez-Mowbray, J. R., Maurel, J.   +9 more
openaire   +5 more sources

Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis

Epidemiology and Health, 2021
OBJECTIVES Biliary tract cancers (BTCs) are rare but highly fatal. Although the etiology of BTC is poorly understood, gallstones are proposed to be a major risk factor.
Dan Huang, Hyundeok Joo, N. Song, Sooyoung Cho, W. Kim, A. Shin   +5 more
semanticscholar   +1 more source