Results 91 to 100 of about 2,597,010 (305)

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Precursors to Cholangiocarcinoma

Gastroenterology Research and Practice, 2019
Cancers of the biliary tract include intra- and extrahepatic cholangiocarcinomas and gallbladder cancer. Biliary tract cancers are diseases with unfavorable prognoses.
Tomas Hucl
doaj   +1 more source

Clinical Course and Morphological Features of Chronic Gastritis in Patients with the Most Common Gastroenterological Pathology

Gastroenterologìa, 2014
The article deals with the features of clinical course and morphological state of gastric mucosa in patients with the most common gastroenterological diseases, namely: gallbladder and biliary tract diseases, non-alcoholic fatty liver disease, functional ...
A.S. Svintsytskyi, H.A. Soloviova, O.H. Kuryk, N.Ye. Dolhaia, I.V. Korendovych   +4 more
doaj   +1 more source

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis [PDF]

, 2011
Background/Aims: The chromosome 4q27 region harboring IL2 and IL21 is an established risk locus for ulcerative colitis (UC) and various other autoimmune diseases.
Denk, Gerald Ulrich, Brand, Stephan, Burkhard Göke, Göke, Burkhard, Stephan Brand, Rüdiger Paul Laubender, Christian Rust, Johannes Stallhofer, Jürgen Glas, Laubender, Rüdiger Paul, Glas, Jürgen, Pusl, Thomas, Thomas Pusl, Gerald Ulrich Denk, Stallhofer, Johannes, Rust, Christian   +15 more
core   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Research progress on the association between biliary microbiota and the presence of biliary tract diseases as well as the postoperative infections

Shanghai yufang yixue
The biliary microbiota is an important component of the biliary system, the structure changes and dysbiosis of the biliary microbiota are closely related to the occurrence and development of biliary diseases.
YANG Xinran, ZHOU Yuyang, YAN Zhe
doaj   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Issues of therapy for biliary pathology in children: the choice of the optimal solution

Zdorovʹe Rebenka, 2018
Background. Diseases of the hepatobiliary system are one of the most important problems of pediatric gastroentero­logy. Lesions of the biliary tract are associated with persistent changes in lipid metabolism that contributes to the prolonged cholestasis ...
O.V. Shutova, N.V. Pavlenko, O.N. Babadganyan, I.G. Solodovnichenko, O.V. Buksha   +4 more
doaj   +1 more source

Some features of sclerotic processes in the walls of the bile ducts and gall bladder in chronic bile tract diseases (a review of literature)

Известия высших учебных заведений. Поволжский регион: Медицинские науки, 2022
The article presents the results of studies of variants of the development of sclerotic changes in the liver tissue, intrahepatic and extrahepatic ducts, as well as the walls of the gallbladder associated with various chronic diseases of the biliary ...
M.G. Fedorova, E.V. Komarova, N.O. Tsyplikhin   +2 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source