Results 121 to 130 of about 93,936 (356)

Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study

British Journal of Clinical Pharmacology, EarlyView.
Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐small‐cell lung cancer (NSCLC) demonstrated a favourable benefit–risk profile. This study evaluated population pharmacokinetics (PopPK) and exposure–response (ER) relationships of durvalumab in patients ...
Xiaoying Zhao, Junjie Ding, Jiajia Zhao, Ling Zhang, Aburough Abegesah, Yu‐qian Zhang, Cathy O'Brien, Gary J. Doherty, Allen C. Chen, KyoungSoo Lim, Song Ren, Peiming Ma, Diansong Zhou   +12 more
wiley   +1 more source

[Internal biliary diversions in inoperable neoplasms of the biliary tract and pancreas].

Il Giornale di chirurgia, 1991
The authors report their experience with the treatment of mechanical jaundice in inoperable malignant neoplasms of the bile ducts and pancreas. They emphasize the importance of intrahepatic peripheral biliodigestive derivations (Soupault and Couinaud operation).
G, Giordano, T, Losacco, G, Garofalo, F, Grimaldi, G, Petracca, N, Mustacchio, D, Novelli, G, Cannone, G, Carbonara   +8 more
openaire   +1 more source

Durvalumab plus gemcitabine-cisplatin versus S-1 plus gemcitabine-cisplatin in advanced biliary tract cancer: a comparative study

ESMO Gastrointestinal Oncology
Background and purpose: Following the TOPAZ-1 trial, chemoimmunotherapy with durvalumab plus gemcitabine and cisplatin (GCD) became the standard first-line treatment of advanced biliary tract cancer (BTC).
T. Satake, M. Sasaki, H. Imaoka, S. Taro, K. Inoue, T. Taira, G. Igarashi, M. Amisaki, H. Takahashi, S. Mitsunaga, M. Ikeda   +10 more
doaj   +1 more source

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

FOLFIRI as second-line treatment of metastatic biliary tract cancer patients

Autopsy and Case Reports, 2019
The combination of cisplatin and gemcitabine is the standard first-line treatment of metastatic biliary tract cancer (BTC) patients. The benefit of second-line chemotherapy in these patients is controversial.
Rafael Caparica, Adrien Lengelé, Winnie Bekolo, Alain Hendlisz   +3 more
doaj  

Multiple metallic stents placement for malignant hilar biliary obstruction: Perspective of a radiologist

Gastrointestinal Intervention, 2016
In the palliative setting, the necessity of biliary drainage of both liver lobes for malignant hilar biliary obstruction remains controversial. However, bilateral biliary drainage is a reasonable option to prevent cholangitis of the undrained lobe and to
Yozo Sato, Yoshitaka Inaba, Kazuo Hara, Hidekazu Yamaura, Mina Kato, Shinichi Murata, Yui Onoda   +6 more
doaj   +1 more source

Role of the Choline‐Binding Protein A in the Ability of Porcine Ligilactobacillus salivarius FFIG58 to Modulate TLR3‐Mediated Intestinal Antiviral Immunity

Food Frontiers, EarlyView.
The choline‐binding protein A (CbpA) was shown to mediate adhesion of probiotic Ligilactobacillus salivarius strains to human intestinal epithelial cells (IECs). A knockout mutant lacking the CbpA protein derived from the immunomodulatory porcine strain L. salivarius FFIG58 was obtained. The CbpA is a key surface protein of L.
Yoshiya Imamura, Hikari Yamamuro, Mariano Elean, Lorena Paola Arce, Ryutaro Funabashi, Fernanda Raya Tonetti, Kohtaro Fukuyama, Mikado Tomokiyo, Fu Namai, Sudeb Saha, Wakako Ikeda‐Ohtsubo, Keita Nishiyama, Julio Villena, Haruki Kitazawa   +13 more
wiley   +1 more source

Sulfated Polysaccharides in the Hallmarks of Metabolic Syndrome: Functions and Mechanisms

Food Frontiers, Volume 7, Issue 1, January 2026.
The SPs sources are very diverse, including various fishes, sea cucumbers, seaweeds, etc. These SPs are able to improve the glucose and lipid metabolism disorders, hormonal dysregulation, oxidative stress, inflammatory response, complications, and gut homeostasis of MetS by regulating biochemical indicators related to MetS. ABSTRACT Metabolic syndrome (
Fuqiang Zhao, Chuan Li, Xin Zhang, Kexue Zhu, Chao Zhao, Deming Gong, Lulu Zhu, Yongcheng Li, Jun Cao, Shaoping Nie   +9 more
wiley   +1 more source

Magnetic Resonance Imaging versus Computed Tomography for Biliary Tract Intraductal Papillary Mucinous Neoplasm (BT-IPMN): A Diagnostic Performance Analysis

, 2020
Jing Li, Yuanlin Yu, Lulong Zhu, Yuping Li, Qing He   +4 more
openalex   +2 more sources

Renoprotective Effect of Coix lachryma‐jobi L. Seed Polysaccharides in Adenine‐Induced Chronic Renal Failure by Blocking Gut Urea Metabolism

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Dietary soluble fiber may alleviate renal damage in chronic kidney disease (CKD) by promoting intestinal urea excretion, though the underlying mechanisms remain unclear. This study investigated the digestion, fermentation, and renoprotective effects of Coix lachryma‐jobi L.
Hongmei Yin, Wanjun Liao, Yilian Huang, Qiang Hong, Na Zhang, Xiaodan Shi, Zongcai Tu, Hui Wang, Zuohua Xie, Tao Yuan   +9 more
wiley   +1 more source