CircHECTD1 Promotes Cholangiocarcinoma Progression Through Interaction With SFPQ to Induce Autophagy
Cancer Science, EarlyView.CircHECTD1 directly interacts with SFPQ to upregulate ATG12 expression, thereby activating autophagy and promoting cholangiocarcinoma progression. This study uncovers a noncanonical circRNA–RNA‐binding protein regulatory mechanism and provides a potential therapeutic target for cholangiocarcinoma.
Shouwen Zhao +11 more
wiley +1 more source
Diagnosis and treatment of cholecystogastric fistula: a case report. [PDF]
Front SurgChen B, Luo W.
europepmc +1 more source
Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria
Cancer Science, EarlyView.Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren +11 more
wiley +1 more source
Laparoscopic management of an unexpected cholecystogastric fistula discovered during common bile duct exploration: a case report and focused literature review. [PDF]
Ann Med Surg (Lond)Nishad SR +6 more
europepmc +1 more source
Cell Proliferation, EarlyView.In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar +5 more
wiley +1 more source
Economic Burden of Overweight and Obesity in Sweden: Current Estimates and Future Projections
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Overweight and obesity are major public health challenges and well‐established risk factors for cardiovascular disease, cancer and premature mortality. We estimated the economic burden of overweight and obesity in Sweden in 2023 and projected the future economic burden in 2040 under alternative scenarios of increasing prevalence ...
Adam Fridhammar +5 more
wiley +1 more source
Durable response to sotorasib in KRAS G12C-mutant intrahepatic cholangiocarcinoma: a case report. [PDF]
OncologistLiu C, Li K, Feng J.
europepmc +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review
The FEBS Journal, EarlyView.This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas +11 more
wiley +1 more source
Spectrum of Biliary and Nonbiliary Neoplasms Growing and Spreading Within the Lumen of the Bile Ducts. [PDF]
Cancers (Basel)Nakanuma Y, Sato Y, Kakuda Y, Oishi T.
europepmc +1 more source