Results 221 to 230 of about 242,163 (312)

The Impact of <i>UGT1A1</i> Genetic Variability on Enzyme Expression in Liver Pathology. [PDF]

Genes (Basel)
Szeląg-Pieniek S, Kucak J, Malinowski D, Oswald S, Droździk M, Kurzawski M.   +5 more
europepmc   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Ursodeoxycholic Acid in the Management of Prolonged Neonatal Hyperbilirubinemia: A Randomized Controlled Clinical Trial. [PDF]

Iran J Med Sci
Tabrizi M, Mahdipour S, Hoseini Nouri SA, Aminzadeh V, Ghadiri Z, Shahrokhi M.   +5 more
europepmc   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Artificial Liver Support Effectively Removes Immunosuppressive Bile Acids From Circulation in Patients With Severe Liver Failure: A Proof of Concept Study. [PDF]

Crit Care Explor
Leonhardt J, Schmidt HH, Koball S, Dollinger M, Wilms C, Neugebauer S, Kunze J, Kiehntopf M, Hinz M, Backhus J, Henschel J, Klammt S, Sponholz C, Dominik A, Mitzner S, Stange J, Bauer M, Kortgen A.   +17 more
europepmc   +1 more source

Serum Apelin‐13 and Galectin‐3 in COVID‐19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case–Control Study

Journal of Clinical Laboratory Analysis, EarlyView.
Serum Apelin‐13 and Galectin‐3 levels were measured by ELISA in COVID‐19–positive patients and controls and evaluated alongside routine biochemical parameters. COVID‐19 patients showed significant alterations in liver, renal, inflammatory, and metabolic markers.
İsmail Uğurlu
wiley   +1 more source

Dubin-Johnson and Rotor Syndromes: A Review and Update of Pathophysiological Mechanisms. [PDF]

J Clin Transl Hepatol
Thakkar B, Wu GY.
europepmc   +1 more source

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole‐Genome Sequencing: A De Novo 11q14.3–q22.3 Deletion and a Splicing‐Altering Synonymous ANK1 Variant

Journal of Clinical Laboratory Analysis, EarlyView.
Clinical utility of trio WGS and time metrics in a neonate with congenital anomalies and hemolytic anemia. ABSTRACT Background Neonates with complex and evolving phenotypes often lack sufficiently specific clinical features to guide targeted genetic testing.
Hyun‐Woo Lee, Ja‐Hyun Jang, Beom Hee Lee, Hee‐Jeong Youk, Eun Sun Kim, Kee Hyun Cho, Yun Sil Chang, Heui Seung Jo, Mi‐Ae Jang   +8 more
wiley   +1 more source

Phototherapy, Morbidity, and Mortality in Very Preterm Newborns.

JAMA Netw Open
Deschmann E, Håkansson S, Söderling J, Norman M.   +3 more
europepmc   +1 more source

Bilirubin directly activates RIPK3 to induce non-classical necroptosis. [PDF]

Cell Discov
Xue Q, Ma X, Chen Z, Ge F, Wu J, Bao W, Zhou L, Yi W, Wu M, Liao S, Xu W, He R, Feng J, Hu Y, Chen X, Wu X, Yan D, Tang D, Chen X, Liu J.   +19 more
europepmc   +1 more source