Results 61 to 70 of about 1,516 (196)

Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rat

, 2013
Standardized Ginkgo biloba extract EGb 761 has been shown to inhibit inflammatory hyperalgesia in rats; however, the mechanism of action is not known. This study set out to investigate the anti-inflammatory and analgesic potential of bilobalide, a unique
Dolan, Sharron; id_orcid, Goldie, Michelle   +1 more
core   +1 more source

Correction to: Bilobalide protects against ischemia/reperfusion-induced oxidative stress and inflammatory responses via the MAPK/NF-κB pathways in rats

BMC Musculoskeletal Disorders, 2020
An amendment to this paper has been published and can be accessed via the original article.
Ying Li, Jiliang Jiang, Liangcheng Tong, Tingting Gao, Lei Bai, Qing Xue, Jianxin Xing, Qin Wang, Haoran Lyu, Min Cai, Zhongyang Sun   +10 more
doaj   +1 more source

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

BioMed Research International, Volume 2026, Issue 1, 2026.
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Aniket Singh, Sanjeev Kumar Sahu, Anil Kumar Sah, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source

Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex

, 2009
Standardized extracts of Ginkgo biloba L. leaves are widely used in clinical practice for the symptomatic treatment of mild to moderate dementia syndromes, cerebral insufficiency and for the enhancement of cognitive function.
G.B. Rossoni, A. Riva, R. Rossi, P. Morazzoni, P. L. Mauri, F. Basilico   +5 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons

, 2009
Loss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of ...
Klein, WL, Lao, L, Tchantchou, F, Yuan Luo, Cao, Z, Luo, Y, Lixing Lao, Cui, C, Zhiming Cao, William L. Klein, Pascale N. Lacor, Changhai Cui, Lacor, PN, Hou, Y, Yan Hou, Flaubert Tchantchou   +15 more
core   +1 more source

Potassium chloride elicits enhancement of bilobalide and Ginkgolides production by Ginkgo biloba cell cultures [PDF]

, 2010
This study investigated the ability of potassium chloride (KCl) to elicit the production of bilobalide (BB), ginkgolide A (GA) and ginkgolide B (GB) by Ginkgo biloba cell suspension cultures.
Myung Suk Choi, ., Mi Jin Jeong, Dong Jin Park, Ji Yun Min, Jae Kyung Yang, Chandrakant, S.K., Chang Mi Heo, Seung Mi Kang, Chang Mi Heo, ., Hyun Jin Song, Mi Jin Jeong, ., Chandrakant S. Karigar, Hak Gon Kim, Dong Jin Park, ., Seung Mi Kang, ., Hyun Jin Song, ., Jae Kyung Yang, ., Myung Suk Choi, Cheul-Ho Lee, ., Hak Gon Kim, ., Cheul‐Ho Lee, Ji Yun Min, .   +21 more
core   +1 more source

TCMD: A High‐Throughput and Rapid Method for Screening Antimicrobial Ingredients from Renewable Bio‐Based Resources

Advanced Science, Volume 12, Issue 27, July 17, 2025.
This study develops a strategy to screen the active compounds from bio‐mixtures via combining transcriptomic profiling and molecular docking. The proposed method demonstrates 100% correction in three different biobased mixtures and is 3–20 times faster than traditional approaches.
Yongdong Xu, Yueyao Wang, Yongming Chen, Yunxia Wang, Shicheng Zhang, Gang Luo, Fuhao Cui, Taisheng Du, Zhidan Liu   +8 more
wiley   +1 more source

Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor

, 2011
Terpene trilactones from Ginkgo biloba have been investigated extensively for their antioxidant and anti-ischaemic activities on the brain and the heart, but the mechanisms of these effects remain unclear.
Wei Guo, Yi-Zhun Zhu, Stefanie Maerz, Chun-Hua Liu   +3 more
core   +1 more source

Ginkgo biloba Extract EGb 761 Improves Vestibular Compensation and Modulates Cerebral Vestibular Networks in the Rat

Frontiers in Neurology, 2019
Unilateral inner ear damage is followed by behavioral recovery due to central vestibular compensation. The dose-dependent therapeutic effect of Ginkgo biloba extract EGb 761 on vestibular compensation was investigated by behavioral testing and serial ...
Magdalena Lindner, Astrid Gosewisch, Eva Eilles, Christina Branner, Anja Krämer, Rosel Oos, Eckhard Wolf, Sibylle Ziegler, Sibylle Ziegler, Peter Bartenstein, Peter Bartenstein, Peter Bartenstein, Thomas Brandt, Thomas Brandt, Marianne Dieterich, Marianne Dieterich, Marianne Dieterich, Andreas Zwergal, Andreas Zwergal   +18 more
doaj   +1 more source