Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling [PDF]
Antioxidants, 2023 The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents of the extract of Ginkgo biloba, are investigated in silico (level of theory: (SMD)-M06-2X/6-311+G(d,p)//M06-2X/6-31G(d)).
Davide Zeppilli +2 more
exaly +4 more sources
Neuroregulatory role of ginkgolides [PDF]
Molecular Biology Reports, 2021 AbstractThe application of ginkgolides as a herbal remedy reaches ancient China. Over time many studies confirmed the neuroprotective effect of standard Ginkgo biloba tree extract—the only available ginkgolide source. Ginkgolides present a wide variety of neuroregulatory properties, commonly used in the therapy process of common diseases, such as ...
Martyna Gachowska +2 more
exaly +3 more sources
Heliyon, 2015 Objective: To explore the neuroprotective mechanism of Ginkgolides or Ginkgo flavonoids on the TNF-α induced apoptosis of cultured rat hippocampal neurons. Materials and methods: Primary hippocampal neurons were isolated from rat brains and cultured with
Maojuan Guo, Qing Gao, Huan Du
exaly +3 more sources
Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis [PDF]
Frontiers in Pharmacology, 2023 ObjectiveThis study aimed to evaluate the efficacy of combining diterpene ginkgolide meglumine injection (DGMI) with edaravone for the treatment of acute ischemic stroke.
Mingyuan Yan +10 more
doaj +2 more sources
Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology [PDF]
Pharmaceuticals, 2023 Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (
Juan Carlos Gomez-Verjan +4 more
doaj +2 more sources
Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury [PDF]
Frontiers in PharmacologyNeurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. Evidences from several studies suggest that their pathogenesis is related to hypoxia. However, there are certain limitations and adverse
Yuman Zhang +9 more
doaj +2 more sources
Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial [PDF]
Frontiers in PharmacologyBackgroundEndovascular interventional therapy is an important treatment method for cardioembolic stroke. Diterpene Ginkgolides Meglumine Injection (DGMI) may serve as an adjunct to endovascular interventional therapy for acute ischemic stroke ...
Yiping Li +3 more
doaj +2 more sources
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence [PDF]
MetabolitesNeurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation of neuronal structure, or loss of neuronal function, leading to a substantially reduced quality of life.
Enzo Pereira de Lima +10 more
doaj +2 more sources
Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants [PDF]
MoleculesTerpenes, the largest class of plant specialized products, are built from C5 building blocks via terpene synthases and oxidized by cytochrome P450 enzymes (CYPs) for structural diversity.
Maximilian Frey +2 more
doaj +2 more sources
Production of Terpene Trilactones from Cell and Organ Cultures of Ginkgo biloba [PDF]
PlantsGinkgo biloba is an ancient plant that has survived up until the present day. Gingko biloba is a rich source of valuable secondary metabolites, particularly terpene trilactones (TTLs) such as ginkgolides and bilobalides, which are obtained from the ...
Hosakatte Niranjana Murthy +3 more
doaj +2 more sources