Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling [PDF]
Antioxidants, 2023 The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents of the extract of Ginkgo biloba, are investigated in silico (level of theory: (SMD)-M06-2X/6-311+G(d,p)//M06-2X/6-31G(d)).
Marco Bortoli, Giovanni Ribaudo
exaly +4 more sources
Frontiers in Systems Neuroscience, 2020 The inflammatory immune response (IIR) is a physiological or excessive systemic response, induced by inflammatory immune cells according to changes in the internal and external environments.
Kangding Liu, Chunrong Li
exaly +3 more sources
Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury [PDF]
Frontiers in PharmacologyNeurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. Evidences from several studies suggest that their pathogenesis is related to hypoxia. However, there are certain limitations and adverse
Yuman Zhang +9 more
doaj +2 more sources
Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial [PDF]
Frontiers in PharmacologyBackgroundEndovascular interventional therapy is an important treatment method for cardioembolic stroke. Diterpene Ginkgolides Meglumine Injection (DGMI) may serve as an adjunct to endovascular interventional therapy for acute ischemic stroke ...
Yiping Li +3 more
doaj +2 more sources
Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis [PDF]
Frontiers in Pharmacology, 2023 ObjectiveThis study aimed to evaluate the efficacy of combining diterpene ginkgolide meglumine injection (DGMI) with edaravone for the treatment of acute ischemic stroke.
Mingyuan Yan +10 more
doaj +2 more sources
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence [PDF]
MetabolitesNeurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation of neuronal structure, or loss of neuronal function, leading to a substantially reduced quality of life.
Enzo Pereira de Lima +10 more
doaj +2 more sources
Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants [PDF]
MoleculesTerpenes, the largest class of plant specialized products, are built from C5 building blocks via terpene synthases and oxidized by cytochrome P450 enzymes (CYPs) for structural diversity.
Maximilian Frey +2 more
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Production of Terpene Trilactones from Cell and Organ Cultures of Ginkgo biloba [PDF]
PlantsGinkgo biloba is an ancient plant that has survived up until the present day. Gingko biloba is a rich source of valuable secondary metabolites, particularly terpene trilactones (TTLs) such as ginkgolides and bilobalides, which are obtained from the ...
Hosakatte Niranjana Murthy +3 more
doaj +2 more sources
Molecules, 2022 Ginkgolide is a unique terpenoid natural compound in Ginkgo biloba, and it has an important medicinal value. Proper selenium has been reported to promote plant growth and development, and improve plant quality, stress resistance, and disease resistance ...
Linling Li +7 more
doaj +1 more source
Molecules, 2021 The present study compared the effects of natural senescence and methyl jasmonate (JA-Me) treatment on the levels of terpene trilactones (TTLs; ginkgolides and bilobalide), phenolic acids, and flavonoids in the primary organs of Ginkgo biloba leaves ...
Marcin Horbowicz +5 more
doaj +1 more source