Results 21 to 30 of about 2,581 (218)
Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42
Journal of Neuroinflammation, 2004 Background Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β1-42 or the prion protein).
Williams Alun, Salmona Mario, Bate Clive
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
core +2 more sources
Transformation of multi-component ginkgolide into ginkgolide B by Coprinus comatus [PDF]
BMC Biotechnology, 2015 As the strongest antagonist of the platelet activating factor, ginkgolide B (GB) possesses anti-ischemic, anti-oxidant and anti-convulsant properties, and it is used for the treatment of thrombosis in clinical practice. Till now, GB is usually obtained from extraction of Ginkgo biloba leaves through column chromatography with an extremely low yield and
Ding, HongXue +4 more
openaire +2 more sources
Adulteration and Poor Quality of Ginkgo biloba Supplements [PDF]
, 2016 Adulteration of Ginkgo products sold as unregistered supplements within the very large market of Ginkgo products (reputedly £650 million annually) through the post-extraction addition of cheaper (e.g.
Booker, A +4 more
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Ginkgolides protect against amyloid-β1–42-mediated synapse damage
Molecular Neurodegeneration, 2008 Background The early stages of Alzheimer's disease (AD) are closely associated with the production of the Aβ1–42 peptide, loss of synapses and gradual cognitive decline.
Williams Alun, Tayebi Mourad, Bate Clive
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Nature Communications, 2022 Although ginkgo terpenoids have been studied extensively for their pharmaceutical properties, knowledge on their biosynthesis remains limited. Here, the authors identify five multifunctional cytochrome P450s that catalyze the generation of the tert-butyl
Victor Forman +8 more
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Molecules, 2018 In the present study, the process of ultrasonic assisted enzymatic extraction (UAEE), followed by macroporous resin purification, was successfully developed to achieve maximal recovery of flavonoids and ginkgolides from Ginkgo biloba fallen leaves (GBFL).
Guisheng Zhou +5 more
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Herbal medicines from ginkgo leaf extract in the treatment of mild dementia [PDF]
Arhiv za farmaciju, 2020 According to current EU monograph of the Committee on Herbal Medicinal Products of European Medicines Agency (EMA/HMPC) for ginkgo leaf, Ginkgonis folium (Ginkgo biloba, Ginkgoaceae), herbal medicines prepared from refined and quantified dry extract of ...
Petrović Silvana, Ušjak Ljuboš
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Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
, 2007 Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas +30 more
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Nutraceuticals, 2023 The phytochemical profiles of extracts from closed, semi-opened and opened leaf buds and the summer leaves of Ginkgo biloba were studied. The extraction and purification of bilobalide and ginkgolides, using andrographolide as an internal standard, were ...
Dominique Laurain-Mattar +5 more
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