Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial [PDF]
Frontiers in PharmacologyBackgroundEndovascular interventional therapy is an important treatment method for cardioembolic stroke. Diterpene Ginkgolides Meglumine Injection (DGMI) may serve as an adjunct to endovascular interventional therapy for acute ischemic stroke ...
Yiping Li +3 more
doaj +2 more sources
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence [PDF]
MetabolitesNeurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation of neuronal structure, or loss of neuronal function, leading to a substantially reduced quality of life.
Enzo Pereira de Lima +10 more
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Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis [PDF]
Frontiers in Pharmacology, 2023 ObjectiveThis study aimed to evaluate the efficacy of combining diterpene ginkgolide meglumine injection (DGMI) with edaravone for the treatment of acute ischemic stroke.
Mingyuan Yan +10 more
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Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants [PDF]
MoleculesTerpenes, the largest class of plant specialized products, are built from C5 building blocks via terpene synthases and oxidized by cytochrome P450 enzymes (CYPs) for structural diversity.
Maximilian Frey +2 more
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Production of Terpene Trilactones from Cell and Organ Cultures of Ginkgo biloba [PDF]
PlantsGinkgo biloba is an ancient plant that has survived up until the present day. Gingko biloba is a rich source of valuable secondary metabolites, particularly terpene trilactones (TTLs) such as ginkgolides and bilobalides, which are obtained from the ...
Hosakatte Niranjana Murthy +3 more
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Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti-Apoptotic, and Neurotrophic Treatments. [PDF]
Adv Healthc MaterIonizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Akanchise T +4 more
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Synthesis of the Spirotetracyclic Core of the Ginkgolides via a Malonyl Radical Cascade. [PDF]
Org LettThe ginkgolides are a family of terpene trilactone natural products exclusive to the Ginkgo biloba tree. Here, we present a concise synthesis of their spirotetracyclic core via a manganese(III)-mediated oxidative radical cascade.
Hernández-Lladó P +2 more
europepmc +2 more sources
The ginkgolides. IV. Stereochemistry of the ginkgolides
Tetrahedron Letters, 1967 M. Maruyama +5 more
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Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules. [PDF]
Angew Chem Int Ed EnglThe second‐generation crystalline sponge method allows structurally diverse molecular guests to crystallize under standardized crystallization conditions. The key is the predominant packing type of cages and anions in crystals. ABSTRACT Crystallization is typically highly sensitive to even minor structural differences in target molecules.
He W, Takezawa H, Fujita M.
europepmc +3 more sources
Molecules, 2022 Ginkgolide is a unique terpenoid natural compound in Ginkgo biloba, and it has an important medicinal value. Proper selenium has been reported to promote plant growth and development, and improve plant quality, stress resistance, and disease resistance ...
Linling Li +7 more
doaj +1 more source