Results 11 to 20 of about 1,719 (204)
Radical Scavenging Potential of Ginkgolides and Bilobalide: Insight from Molecular Modeling [PDF]
Antioxidants, 2023 The reactive oxygen species (ROS) scavenging capacities of ginkgolides and bilobalide, which are the peculiar constituents of the extract of Ginkgo biloba, are investigated in silico (level of theory: (SMD)-M06-2X/6-311+G(d,p)//M06-2X/6-31G(d)).
Marco Bortoli, Giovanni Ribaudo
exaly +4 more sources
The protective mechanism of Ginkgolides and Ginkgo flavonoids on the TNF-α induced apoptosis of rat hippocampal neurons and its mechanisms in vitro [PDF]
Heliyon, 2015 Objective: To explore the neuroprotective mechanism of Ginkgolides or Ginkgo flavonoids on the TNF-α induced apoptosis of cultured rat hippocampal neurons. Materials and methods: Primary hippocampal neurons were isolated from rat brains and cultured with
Qing Gao, Xijuan Jiang, Maojuan Guo
exaly +4 more sources
Ginkgolides protect against amyloid-β1–42-mediated synapse damage
Molecular Neurodegeneration, 2008 Background The early stages of Alzheimer's disease (AD) are closely associated with the production of the Aβ1–42 peptide, loss of synapses and gradual cognitive decline.
Williams Alun, Tayebi Mourad, Bate Clive
doaj +3 more sources
Total Synthesis of Ginkgolide C and Formal Synthesis Ginkgolides A and B [PDF]
, 2022 Ginkgolides are diterpenes isolated from ginkgo biloba that exhibit strong PAF antagonistic activity as well as other interesting neuroprotective properties. These natural products possess a compact, highly oxygenated hexacyclic structure with two adjacent quaternary carbon centers, an unusual tert-butyl group, and up to twelve contiguous stereogenic ...
Louis Barriault +2 more
openaire +3 more sources
Molecules, 2018 In the present study, the process of ultrasonic assisted enzymatic extraction (UAEE), followed by macroporous resin purification, was successfully developed to achieve maximal recovery of flavonoids and ginkgolides from Ginkgo biloba fallen leaves (GBFL).
Guisheng Zhou +5 more
doaj +2 more sources
Molecules, 2019 Ginkgo tea is a kind of health food produced from Ginkgo biloba leaves. The market of Ginkgo tea encountered many difficulties because of its bad palatability and vague function statement.
Xianying Fang +7 more
doaj +2 more sources
Combining Metabolic Profiling and Gene Expression Analysis to Reveal the Biosynthesis Site and Transport of Ginkgolides in Ginkgo biloba L. [PDF]
Frontiers in Plant Science, 2017 The most unique components of Ginkgo biloba extracts are terpene trilactones (TTLs) including ginkgolides and bilobalide. Study of TTLs biosynthesis has been stagnant in recent years.
Xu Lu +6 more
doaj +2 more sources
Review of neuroprotective potential of natural products against hypoxia-induced neuronal injury [PDF]
Frontiers in PharmacologyNeurological disorders such as neurodegenerative diseases (NDDs) and stroke have become a major global health burden. Evidences from several studies suggest that their pathogenesis is related to hypoxia. However, there are certain limitations and adverse
Yuman Zhang +9 more
doaj +2 more sources
Molecules, 2018 Ginkgolides (GG), containing ginkgolide A (GA), ginkgolide B (GB) and ginkgolide C (GC), are mainly prescribed for ischemic stroke and cerebral infarction. However, the ginkgolides can hardly pass the blood-brain barrier (BBB) into the brain. The purpose
Zhiyang Lv +5 more
doaj +2 more sources