Results 181 to 190 of about 224,890 (308)

Mix Design and Performance Analysis of Concrete with Limestone Powder Admixture. [PDF]

Materials (Basel)
Gong F, Xu M, Wu J, An P, Shi W.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

<i>De novo</i> design of dual-target mini-binders simultaneously neutralizing <i>Streptococcus equi subspecies zooepidemicus</i> M-like protein and host TNFR1 confers complete protection against lethal infection. [PDF]

Mater Today Bio
Ming K, Hu Y, Xing B, Chen M, Chen Y, Chen X, Geng M, Wu Z, Liu Y, Wei L, Weng J, Wei Z.   +11 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Optimization of Mix Proportion and Performance Study of Metakaolin-Slag Geopolymer Mortar Based on Orthogonal Experiment. [PDF]

Materials (Basel)
Liang P, Zhu L, Yin R, Gao R.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Pore-intrusion of polymeric binder in supercapacitor electrodes decreases capacitance.

Nanoscale
Im J, Liu X, O'Keefe CA, Grey CP, Forse AC.   +4 more
europepmc   +1 more source

Investigation on the Fatigue and Rutting Behavior of Asphalt Binder Containing Compound Warm Mixing Agent. [PDF]

Materials (Basel)
Fu Q, Chang T, Yang Q, Zhang N, Huang Z, Yu K, Li Q.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Corrosion Behavior of HVAF-Sprayed WC-10Co-4Cr Coatings in H₂SO₄ and HNO₃ Environments. [PDF]

Materials (Basel)
Chen Y, Wan W, Liang M, Xiao S, Liu W, Song J, Fan K.   +6 more
europepmc   +1 more source