Results 61 to 70 of about 6,725,434 (301)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

\u3cem\u3ePlasmodium falciparum\u3c/em\u3e SSB Tetramer Binds Single-Stranded DNA Only in a Fully Wrapped Mode [PDF]

, 2012
The tetrameric Escherichia coli single-stranded DNA (ssDNA) binding protein (Ec-SSB) functions in DNA metabolism by binding to ssDNA and interacting directly with numerous DNA repair and replication proteins.
Antony, Edwin, Kozlov, Alexander G., Lohman, Timothy M., Nguyen, Binh   +3 more
core   +1 more source

On the role of specific drug binding in modelling arterial eluting stents [PDF]

, 2016
In this paper we consider drug binding in the arterial wall following delivery by a drug-eluting stent. Whilst it is now generally accepted that a non-linear saturable reversible binding model is required to properly describe the binding process, the ...
AR Tzafriri, AR Tzafriri, CM Groh, DA Lauffenburger, F Bozsak, F Bozsak, G Frenning, G Pontrelli, GD Dangas, Giuseppe Pontrelli, RI Hickson, S McGinty, Sean McGinty, TTN Vo   +13 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cells

Journal of Biomedical Science, 2012
Background Platelet-derived growth factor (PDGF) is a potent stimulator of growth and motility of vascular smooth muscle cells (VSMCs). Abnormalities of PDGF/PDGF receptor (PDGFR) are thought to contribute to vascular diseases and malignancy.
Lo Huey-Ming, Tsai Yih-Jeng, Du Wen-Yuan, Tsou Chih-Jen, Wu Wen-Bin   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Donkey anaphora is in-scope binding

Semantics and Pragmatics, 2008
We propose that the antecedent of a donkey pronoun takes scope over and binds the donkey pronoun, just like any other quantificational antecedent would bind a pronoun.
Chris Barker, Chung-chieh Shan
doaj   +1 more source

On a necessary aspect for the Riesz basis property for indefinite Sturm-Liouville problems [PDF]

, 2012
In 1996, H. Volkmer observed that the inequality \[(\int_{-1}^1\frac{1}{|r|}|f'|dx)^2 \le K^2 \int_{-1}^1|f|^2dx\int_{-1}^1\Big|\Big(\frac{1}{r}f'\Big)'\Big|^2dx \] is satisfied with some positive constant $K>0$ for a certain class of functions $f$ on $[-
Beals, Bennewitz, Bennewitz, Bennewitz, Binding, Binding, Brown, Buldygin, Evans, Evans, Evans, Everitt, Hardy, Kac, Karabash, Karabash, Karabash, Kostenko, Kostenko, Parfenov, Pyatkov, Rogozin, Volkmer, Ćurgus   +23 more
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source