Results 61 to 70 of about 4,727,640 (253)

BindingScanner: a tool for predicting binding sites of RNA-binding proteins in transcripts

, 2020
BindingScanner is a tool for predicting binding sites of distinct regulators in an RNA sequence by calculating posterior probabilities with MotEvo, given the sequence specificity of regulators, represented as position-specific weight matrices.
Zavolan, Mihaela, Bak, Maciej, Kanitz, Alexander, Agarwal, Krish, Maciej Bak, Pachkov, Mikhail, Katsantoni, Maria   +6 more
core   +1 more source

Nuclear factor I genomic binding associates with chromatin boundaries [PDF]

, 2013
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation.
Armelle Gaussin, Schmid, Christoph D., Mermod, Nicolas, Jozef Adamcik, Ambrosini, Giovanna, Schmid, C. D., Pjanic, P., Giovanna Ambrosini, Plasari, Genta, Genta Plasari, Bucher, P., Adamcik, Jozef, Kerschgens, J., Christoph D Schmid, Petar Pjanic, Pjanic, Petar, Kerschgens, Jan, Ambrosini, G., Pjanic, Milos, Gaussin, Armelle, Gaussin, A., Pjanic, M., Philipp Bucher, Plasari, G., Jan Kerschgens, Adamcik, J., Giovani Dietler, Bucher, Philipp, Milos Pjanic, Dietler, Giovani, Dietler, G., Schmid, C.D., Nicolas Mermod, Mermod, N.   +33 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Replication Data for: Non-separable Preferences in the Statistical Analysis of Roll Call Votes

Conventional multidimensional statistical models of roll call votes assume that legislators' preferences are additively separable over dimensions. In this article, we introduce an item response model of roll call votes that allows for non-separability ...
Stoetzer, Lukas F., Binding, Garret
core   +1 more source

PB2139: MONITORING OLIGOSECRETORY MULTIPLE MYELOMA USING MALDI-TOF MASS SPECTROMETRY

HemaSphere, 2023
Oscar Berlanga, Cristina Simion, Florence Njere, Amy Rollins, Natalia Panko, Sanchia Sarin, Deanna Willis, Sophie Caprioli, Jane Birtwistle, Syreeta Allen, Gemma Malin, Gabriella Lakos   +11 more
doaj   +1 more source

Hepatoprotective Effects of Met-enkephalin on Acetaminophen-Induced Liver Lesions in Male CBA Mice

Molecules, 2014
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis.
Roko Martinić, Hrvoje Šošić, Petra Turčić, Paško Konjevoda, Aleksandra Fučić, Ranko Stojković, Gorana Aralica, Mario Gabričević, Tin Weitner, Nikola Štambuk   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Erasing the Homunculus as an Ongoing Mission: A Reply to the Commentaries

Journal of Cognition, 2020
In our recent article (Schmidt, Liefooghe, & De Houwer, 2020, this volume), we presented an adaptation of the Parallel Episodic Processing (PEP) model for simulating instruction following and task-switching behaviour.
James R. Schmidt, Baptist Liefooghe, Jan De Houwer   +2 more
doaj   +1 more source