Results 51 to 60 of about 4,288,984 (317)
Using the Intrinsic Fluorescence of DNA to Characterize Aptamer Binding
Molecules, 2022 The reliable, readily accessible and label-free measurement of aptamer binding remains a challenge in the field. Recent reports have shown large changes in the intrinsic fluorescence of DNA upon the formation of G-quadruplex and i-motif structures.
Chang Lu +3 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Why the binding theory doesn’t apply at LF
, 2008 This article argues that the relegation of the binding theory to the C-I interface (LF) is theoretically undesirable and empirically unwarranted. Recent Minimalist research has sought to eliminate the binding theory from UG by reducing its conditions to ...
Hicks, Glyn, Glyn Hicks
core +1 more source
BindingScanner: a tool for predicting binding sites of RNA-binding proteins in transcripts
, 2020 BindingScanner is a tool for predicting binding sites of distinct regulators in an RNA sequence by calculating posterior probabilities with MotEvo, given the sequence specificity of regulators, represented as position-specific weight matrices.
Zavolan, Mihaela +6 more
core +1 more source
Étude du comportement mécanique d’une reliure de la fin du XVe siècle – Le Missel de Cambrai
CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2013 The article concerns the restoration of an incunabula printed in 1495 in Paris. Our goal was to adapt our interventions taking into account the various constituent materials of the medieval book: leather, wood, sewing and fittings.
Lara Meersseman
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Ligand binding and homology modelling of insect odorant-binding proteins [PDF]
, 2014 This review describes the main characteristics of odorant-binding proteins (OBPs) for homology modelling and presents a summary of structure prediction studies on insect OBPs, along with the steps involved and some limitations and improvements.
Mutis, A. +3 more
core +1 more source
Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF
Journal of Oral Microbiology, 2019 Neisseria meningitidis, Haemophilus influenzae, and Moraxella catarrhalis are pathogenic bacteria adapted to reside on human respiratory mucosal epithelia.
Matthew L. Brewer +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2019 Accurate modeling of ligand-binding-site structures plays a critical role in structure-based virtual screening. However, the structures of the ligand-binding site in most predicted protein models are generally of low quality and need refinements. In this
Hugo Guterres (7495277) +2 more
core +1 more source