Results 41 to 50 of about 3,230,220 (267)

S100 Proteins—Intracellular and Extracellular Function in Norm and Pathology

open access: yesBiomolecules
The S100 proteins are small, ubiquitous, mostly homodimeric proteins containing two EF-hand structures, that is, helix-loop-helix motifs specialized in high-affinity calcium-binding (~10−6 M) [...]
Wiesława Leśniak, Anna Filipek
doaj   +1 more source

Reflexivity and adjustment strategies at the interfaces

open access: yesNordlyd: Tromsø University Working Papers on Language & Linguistics, 2011
I argue in this work that Reinhart & Reuland’s (1993) conditions A and B hold for Spanish. I provide evidence supporting the hypothesis that this language makes use of both SE and SELF-anaphors.
Ismael Teomiro
doaj   +1 more source

Binding constraints as instructions of binding machines [PDF]

open access: yesProceedings of the 18th conference on Computational linguistics -, 2000
Binding constraints have resisted to be fully integrated into the course of grammatical processing despite its practical relevance and cross-linguistic generality. The ultimate root for this is to be found in the exponential "overgenerate & filter" procedure of the mainstream rationale for their satisfaction.
openaire   +2 more sources

Phosphate‐binding sequences in nucleotide‐binding proteins [PDF]

open access: yesFEBS Letters, 1985
In the three‐dimensional model of adenylate kinase, the phosphate‐binding site for AMP and ATP has been identified [Pai, E.F. et al. (1977) J. Mol. Biol. 114, 37‐45]. In this region one can distinguish a sequence glycine XXXX glycinelysine. The same sequence is found in many other mononucleotide‐binding proteins including elongation factors and ...
Möller, W., Amons, R.
openaire   +2 more sources

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean   +7 more
wiley   +1 more source

MSALigMap—A Tool for Mapping Active-Site Amino Acids in PDB Structures onto Known and Novel Unannotated Homologous Sequences with Similar Function

open access: yesLife, 2022
MSALigMap (Multiple Sequence Alignment Ligand Mapping) is a tool for mapping active-site amino-acid residues that bind selected ligands on to target protein sequences of interest.
Sameer Hassan   +3 more
doaj   +1 more source

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig   +7 more
wiley   +1 more source

Using the Intrinsic Fluorescence of DNA to Characterize Aptamer Binding

open access: yesMolecules, 2022
The reliable, readily accessible and label-free measurement of aptamer binding remains a challenge in the field. Recent reports have shown large changes in the intrinsic fluorescence of DNA upon the formation of G-quadruplex and i-motif structures.
Chang Lu   +3 more
doaj   +1 more source

Leptin Binding and Binding Capacity in Serum [PDF]

open access: yesClinical Chemistry, 2000
Abstract Background: Leptin, a hormone produced primarily by adipose tissue, is known to be present in serum as both monomeric (free) and higher molecular mass (bound) forms, but little is known about the nature of the bound forms or physiological variation in binding capacity.
openaire   +2 more sources

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier   +11 more
wiley   +1 more source

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