Results 31 to 40 of about 3,230,220 (267)
Temporary amnesia from sleep loss: A framework for understanding consequences of sleep deprivation
Frontiers in Neuroscience, 2023 Throughout its modern history, sleep research has been concerned with both the benefits of sleep and the deleterious impact of sleep disruption for cognition, behavior, and performance.
Paul Whitney +5 more
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Frontiers in Immunology, 2019 Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant ...
Felicity Kendrick +4 more
doaj +1 more source
PLoS Computational Biology, 2013 Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration.
Melanie I. Stefan, Nicolas Le Novère
openaire +6 more sources
Time-Based Binding as a Solution to and a Limitation for Flexible Cognition
Frontiers in Psychology, 2022 Why can’t we keep as many items as we want in working memory? It has long been debated whether this resource limitation is a bug (a downside of our fallible biological system) or instead a feature (an optimal response to a computational problem).
Mehdi Senoussi +2 more
doaj +1 more source
To Bind or Not to Bind: Unravelling GPCR Polypharmacology [PDF]
Cell, 2018 Interaction of a single drug with multiple targets through "polypharmacology" is increasingly recognized as necessary for treatment of complex diseases, such as schizophrenia. G protein-coupled receptors (GPCRs) are major medicinal targets, and understanding the structural basis of both GPCR drug selectivity and promiscuity could provide novel avenues ...
Patrick M, Sexton, Arthur, Christopoulos
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MATEC Web of Conferences, 2016 The authors developed a multi-component gypsum binder (MGB) with an improved (by 1.8 to 2.2 times) water resistance value in comparison with the initial gypsum and a softening factor value within the range of 0.85 to 0.91 through the introduction of a ...
Panchenko Alexander I., Kozlov Nikita
doaj +1 more source
Frontiers in Physiology, 2021 The spontaneous formation of a protein corona on a nanoparticle surface influences the physiological success or failure of the synthetic nanoparticle as a drug carrier or imaging agent used in vivo.
Joanna Xiuzhu Xu, Nicholas C. Fitzkee
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A binding rule for Government-binding parsing [PDF]
Proceedings of the 12th conference on Computational linguistics -, 1988 In this paper I propose a Binding rule for the identification of pronoun and anaphor referents in phrase-structure tress, assuming the general framework of the Government-binding theory outlined by Chomsky (1981). The Binding rule, specified by means of an attribute grammar, is a particular instantiation of the Free Indexing rule and binding axioms in ...
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen +21 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source