Results 51 to 60 of about 1,041,210 (312)

Competitive aptamer switch for modulating ligand binding affinity

Advanced Agrochem, 2023
Aptamers are short, single-stranded DNA or RNA molecules that selectively bind to a target molecule. Aptamer-complement duplex (ACD) is often used to design molecular switches capable of producing a detectable signal or triggering a structural change ...
Derek Puyat, Sung Won Oh, Shiming Liu, Jinglin Fu, Ph.D   +3 more
doaj   +1 more source

Affinity-Selected Bicyclic Peptide G‑Quadruplex Ligands Mimic a Protein-like Binding Mechanism [PDF]

, 2020
The study of G-quadruplexes (G4s) in a cellular context has demonstrated links between these nucleic acid secondary structures, gene expression, and DNA replication.
Kim C. Liu (8740296), Clemens Mayer (6737843), David J. Wales (246398), Shankar Balasubramanian (9301), Shankar Balasubramanian, Santosh Adhikari (5334329), Clemens Mayer, Konstantin Röder (3727960), David J. Wales, Konstantin Röder, Santosh Adhikari, Kim C. Liu   +11 more
core   +1 more source

Dissecting the impact of target-binding kinetics of protein binders on tumor localization

iScience, 2021
Summary: Systematic control of in vivo behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has ...
Yunjin Song, Hoibin Jeong, Song-Rae Kim, Yiseul Ryu, Jonghwi Baek, Jinhak Kwon, Hyeongjun Cho, Kil-Nam Kim, Joong-jae Lee   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Effects of data quality and quantity on deep learning for protein-ligand binding affinity prediction [PDF]

, 2022
Prediction of protein-ligand binding affinities is crucial for computational drug discovery. A number of deep learning approaches have been developed in recent years to improve the accuracy of such affinity prediction. While the predicting power of these
Shi, Yun, Fan, Frankie J
core   +1 more source

Toxic metals (Ni2+, Pb2+, Hg2+) binding affinity of dissolved organic matter (DOM) derived from different ages municipal landfill leachate

Applied Water Science, 2018
Solid waste production is rapidly increasing in Bangladesh and landfill leachate is the consequence of the decomposition of this waste. These leachates contain heavy metals and significant amount of dissolved organic matter (DOM).
S. Y. Rikta, Shafi M. Tareq, M. Khabir Uddin   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Folding-Docking-Affinity framework for protein-ligand binding affinity prediction

Communications Chemistry
Accurate protein-ligand binding affinity prediction is crucial in drug discovery. Existing methods are predominately docking-free, without explicitly considering atom-level interaction between proteins and ligands in scenarios where crystallized protein ...
Ming-Hsiu Wu, Ziqian Xie, Degui Zhi
doaj   +1 more source

The dataset for protein–RNA binding affinity [PDF]

Protein Science, 2013
AbstractWe have developed a non‐redundant protein–RNA binding benchmark dataset derived from the available protein–RNA structures in the Protein Database Bank. It consists of 73 complexes with measured binding affinity. The experimental conditions (pH and temperature) for binding affinity measurements are also listed in our dataset.
Xiufeng, Yang, Haotian, Li, Yangyu, Huang, Shiyong, Liu   +3 more
openaire   +2 more sources