Results 1 to 10 of about 834,721 (279)

Supported Lipid Bilayers and the Study of Two-Dimensional Binding Kinetics [PDF]

Frontiers in Molecular Biosciences, 2022
Binding between protein molecules on contacting cells is essential in initiating and regulating several key biological processes. In contrast to interactions between molecules in solution, these events are restricted to the two-dimensional (2D) plane of ...
Tommy Dam, Manto Chouliara, Victoria Junghans, Peter Jönsson   +3 more
doaj   +2 more sources

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +2 more sources

Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2022
Frontiers Production Office
doaj   +2 more sources

A Radiolabeled Photoswitchable G Protein-Coupled Receptor Antagonist Enlightens Ligand Binding Kinetics Associated with Photoswitching. [PDF]

J Am Chem Soc
Binkhorst LCP, Josimovic I, De Boer B, Simon IA, Van Der Aa F, Zarzycka BA, De Esch IJP, Vischer HF, Windhorst AD, Wijtmans M, Leurs R.   +10 more
europepmc   +2 more sources

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +2 more sources

Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR

Biosensors, 2022
Cholesterol, an important lipid in animal membranes, binds to hydrophobic pockets within many soluble proteins, transport proteins and membrane bound proteins.
Peng He, Shannon Faris, Reddy Sudheer Sagabala, Payel Datta, Zihan Xu, Brian Callahan, Chunyu Wang, Benoit Boivin, Fuming Zhang, Robert J. Linhardt   +9 more
doaj   +1 more source

Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology

Frontiers in Pharmacology, 2021
We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were ...
Krisztina Pesti, Krisztina Pesti, Mátyás C. Földi, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Adam V. Toth, Peter Lukacs, Peter Lukacs, Arpad Mike, Arpad Mike   +10 more
doaj   +1 more source

Unraveling the binding microprocess of individual Streptococcus mutans cells via sucrose-dependent adhesion based on surface plasmon resonance imaging

Journal of Oral Microbiology, 2022
The initial microprocess of a major cariogenic bacterium Streptococcus mutans forming biofilm at a single-cell level via sucrose-dependent adhesion has not been observed because the cells’ high moisture content caused measurement challenges. To develop a
Yuhao Guo, Bo Li, Tengfei Ma, Emily R. Moore, Huixu Xie, Chenzhou Wu, Longjiang Li   +6 more
doaj   +1 more source

Two-dimensional measurements of receptor-ligand interactions

Frontiers in Molecular Biosciences, 2023
Gaining insight into the two-dimensional receptor-ligand interactions, which play a significant role in various pivotal biological processes such as immune response and cancer metastasis, will deepen our understanding of numerous physiological and ...
Songjie Zheng, Songjie Zheng, Min Zou, Min Zou, Yingfeng Shao, Huaping Wu, Helong Wu, Xiaohuan Wang   +7 more
doaj   +1 more source

Anomalous relaxation kinetics of biological lattice-ligand binding models [PDF]

, 2002
We discuss theoretical models for the cooperative binding dynamics of ligands to substrates, such as dimeric motor proteins to microtubules or more extended macromolecules like tropomyosin to actin filaments.
Anon, Durham B., Frendreis S. G. V., Savitzky A., Schöttle U. M., Van Driest E. R., Whittaker S.E.   +6 more
core   +3 more sources