Results 121 to 130 of about 3,018,689 (332)

Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal

open access: yesViruses
During HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag–Psi interactions, there is almost no information on
Constance Rink   +3 more
doaj   +1 more source

Robot‐Assisted Automated Serial‐Sectioning and Imaging for 3D Microstructural Investigations

open access: yesAdvanced Engineering Materials, EarlyView.
A fully automated 3D microstructure characterization platform provides new insights into materials. This robot‐assisted system performs serial‐sectioning, etching, and optical imaging to generate large‐volume 3D reconstructions with submicron resolution.
Michael Moschetti   +7 more
wiley   +1 more source

Structural mechanisms of binding kinetics [PDF]

open access: yes, 2020
Human protein kinases play essential roles in cellular signaling pathways and - if deregulated - are linked to a large diversity of diseases such as cancer and inflammation or to metabolic diseases. Because of their key role in disease development or progression, kinases have developed into major drug targets resulting in the approval of 52 kinase ...
openaire  

Understanding and Optimizing Li Substitution in P2‐Type Sodium Layered Oxides for Sodium‐Ion Batteries

open access: yesAdvanced Functional Materials, EarlyView.
This work explores Li‐substituted P2 layered oxides for Na‐ion batteries by crystallographic and electrochemical studies. The effect of lithium on superstructure orderings, on phase transitions during synthesis and electrochemical cycling and on the interplay of O‐ versus TM‐redox is revealed via various advanced techniques, including semi‐simultaneous 
Mingfeng Xu   +5 more
wiley   +1 more source

Enhancing Low‐Temperature Performance of Sodium‐Ion Batteries via Anion‐Solvent Interactions

open access: yesAdvanced Functional Materials, EarlyView.
DOL is introduced into electrolytes as a co‐solvent, increasing slat solubility, ion conductivity, and the de‐solvent process, and forming an anion‐rich solvent shell due to its high interaction with anion. With the above virtues, the batteries using this electrolyte exhibit excellent cycling stability at low temperatures. Abstract Sodium‐ion batteries
Cheng Zheng   +7 more
wiley   +1 more source

In Situ and Label-Free Quantification of Membrane Protein–Ligand Interactions Using Optical Imaging Techniques: A Review

open access: yesBiosensors
Membrane proteins are crucial for various cellular processes and are key targets in pharmacological research. Their interactions with ligands are essential for elucidating cellular mechanisms and advancing drug development.
Caixin Huang   +5 more
doaj   +1 more source

Insights into Allosteric Control of Human Blood Group A and B Glycosyltransferases from Dynamic NMR

open access: yesChemistryOpen, 2019
Human blood group A and B glycosyltransferases (GTA, GTB) are retaining glycosyltransferases, requiring a catalytic mechanism that conserves the anomeric configuration of the hexopyranose moiety of the donor substrate (UDP‐GalNAc, UDP‐Gal).
Dr. Friedemann Flügge   +1 more
doaj   +1 more source

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