Results 131 to 140 of about 834,721 (279)

Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

mAbs
Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn).
Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer   +3 more
doaj   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

In Situ and Label-Free Quantification of Membrane Protein–Ligand Interactions Using Optical Imaging Techniques: A Review

Biosensors
Membrane proteins are crucial for various cellular processes and are key targets in pharmacological research. Their interactions with ligands are essential for elucidating cellular mechanisms and advancing drug development.
Caixin Huang, Jingbo Zhang, Zhaoyang Liu, Jiying Xu, Ying Zhao, Pengfei Zhang   +5 more
doaj   +1 more source

In vitroandin silicoanalysis of the effects ofD₂receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations [PDF]

, 2018
Wilhelmus E. A. de Witte, Joost W Versfelt, Maria Kuzikov, Solene Rolland, Victoria Georgi, Philip Gribbon, Sheraz Gul, Dymphy Huntjens, Piet Hein van der Graaf, Meindert Danhof, Amaury E. Fernández‐Montalván, Gesa Witt, Elizabeth C. M. de Lange   +12 more
openalex   +1 more source

Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics [PDF]

, 2023
Carrie S. Tambo, Sarvind Tripathi, B. Gayani K. Perera, Dustin J. Maly, Alexander J. Bridges, Gert Kiss, Seth M. Rubin   +6 more
openalex   +1 more source

Self‐supportive Three‐Way Photoelectrochemical System Achieving Uranium Recycling, Organic Oxidation, and Electricity Generation in Complex Waters

Advanced Functional Materials, EarlyView.
A self‐sustaining solar photoelectrochemical cell (SS‐PEC) is developed to recover uranium from aqueous UO22+ with concurrent organic oxidation and electricity production. The monolithical photoanode directly captures electrons from organic compounds, leading to the oxidation of organic compounds and the decomposition of uranium‐organic complexes ...
Yumei Wang, Qingming Zeng, Haodong Ji, Rongzhong Wang, Jiachen Wang, Yanjun Wen, Wonyong Choi, Qingyi Zeng   +7 more
wiley   +1 more source

Dielectric Surface-Based Biosensors for Enhanced Detection of Biomolecular Interactions: Advances and Applications

Biosensors
Surface plasmon resonance (SPR) biosensors are extensively utilized for analyzing molecular interactions due to their high sensitivity and label-free detection capabilities.
Liangju Li, Jingbo Zhang, Yacong Li, Caixin Huang, Jiying Xu, Ying Zhao, Pengfei Zhang   +6 more
doaj   +1 more source

The Domain Structure of ICAM-1 and the Kinetics of Binding to Rhinovirus [PDF]

, 1998
José M. Casasnovas, J K Bickford, Timothy A. Springer   +2 more
openalex   +1 more source

Composition and Resulting Band Alignment at the TiO2/InP Heterointerface: A Fundamental Study Combining Photoemission Spectroscopy and Theory

Advanced Functional Materials, EarlyView.
The chemical composition and band alignment are systematically investigated at the TiO2/InP heterointerface. Thin TiO2 films are deposited by ALD on atomically ordered, P‐terminated p‐InP(100). By combining UPS, XPS, and ab initio molecular dynamics, the atomistic structure and electronic alignment are revealed.
Mohammad Amin Zare Pour, Muhammad Nawaz Qaisrani, Christian Höhn, Johannes Laurenz Wolf, Negin Mogharehabed, Jennifer Velazquez Rojas, Wolfram Jaegermann, Erich Runge, Roel van de Krol, Thomas Hannappel, Christian Dreßler, Agnieszka Paszuk   +11 more
wiley   +1 more source

Selective Benzene Capture by Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) hold significant potential for capturing benzene from air emissions and hydrocarbon mixtures in liquid phases. This capability stems from their precisely engineered structures, versatile chemistries, and diverse binding interactions.
Zongsu Han, Ankit Mondal, Jiatong Huo, Yihao Yang, Hong‐Cai Zhou   +4 more
wiley   +1 more source