Results 11 to 20 of about 3,018,689 (332)

A Review on Perception of Binding Kinetics in Affinity Biosensors: Challenges and Opportunities [PDF]

ACS Omega
There are challenges associated with design and development of affinity biosensors due to the complicated multiphysics nature of the system. Understanding the binding interaction between target molecules and immobilized receptors and its kinetics is a ...
Benjamin McCann, Brandon Tipper, Sepeedeh Shahbeigi, Morteza Soleimani, Masoud Jabbari, M. Nasr Esfahani   +5 more
semanticscholar   +2 more sources

Supported Lipid Bilayers and the Study of Two-Dimensional Binding Kinetics [PDF]

Frontiers in Molecular Biosciences, 2022
Binding between protein molecules on contacting cells is essential in initiating and regulating several key biological processes. In contrast to interactions between molecules in solution, these events are restricted to the two-dimensional (2D) plane of ...
Tommy Dam, Manto Chouliara, Victoria Junghans, Peter Jönsson   +3 more
doaj   +2 more sources

Erratum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2022
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doaj   +2 more sources

A Radiolabeled PhotoswitchableG Protein-Coupled ReceptorAntagonist Enlightens Ligand Binding Kinetics Associated with Photoswitching [PDF]

J Am Chem Soc
Lars C. P. Binkhorst (21606593), Ivana Josimovic (21606596), Bas De Boer (21606599), Icaro A. Simon (13783655), Frank Van Der Aa (8111990), Barbara A. Zarzycka (17145426), Iwan J. P. De Esch (2642917), Henry F. Vischer (726993), Albert D. Windhorst (3567359), Maikel Wijtmans (1723222), Rob Leurs (120648)   +10 more
openalex   +2 more sources

Label-Free Imaging of Single Proteins and Binding Kinetics Using Total Internal Reflection-Based Evanescent Scattering Microscopy.

Analytical Chemistry, 2022
Single-molecule detection can push beyond ensemble averages and reveal the statistical distributions of molecular properties. Measuring the binding kinetics of single proteins also represents one of the critical and challenging tasks in protein analysis.
Pengfei Zhang, Rui Wang, Zijian Wan, Xinyu Zhou, Guangzhong Ma, J. Kolay, Jiapei Jiang, Shaopeng Wang   +7 more
semanticscholar   +1 more source

Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR

Biosensors, 2022
Cholesterol, an important lipid in animal membranes, binds to hydrophobic pockets within many soluble proteins, transport proteins and membrane bound proteins.
Peng He, Shannon Faris, Reddy Sudheer Sagabala, Payel Datta, Zihan Xu, Brian Callahan, Chunyu Wang, Benoit Boivin, Fuming Zhang, Robert J. Linhardt   +9 more
doaj   +1 more source

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance We performed an in-cell screen of imatinib binding against a library of Abl kinase mutants derived from patients with imatinib-resistant chronic myeloid leukemia.
Agatha Lyczek, B. Berger, Aziz M. Rangwala, YiTing Paung, J. Tom, Hannah Philipose, Jiaye Guo, Steven K. Albanese, M. Robers, S. Knapp, J. Chodera, M. Seeliger   +11 more
semanticscholar   +1 more source

Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors

Frontiers in Pharmacology, 2020
In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gαi/o-coupled dopamine D2-like receptors (D2R, D3R, D4R) have previously been ...
Richard Ågren, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +3 more
doaj   +1 more source

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential [PDF]

Frontiers in Physiology, 2023
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +2 more sources

Instrument-Free Protein Microarray Fabrication for Accurate Affinity Measurements

Biosensors, 2020
Protein microarrays have gained popularity as an attractive tool for various fields, including drug and biomarker development, and diagnostics. Thus, multiplexed binding affinity measurements in microarray format has become crucial.
Iris Celebi, Matthew T. Geib, Elisa Chiodi, Nese Lortlar Ünlü, Fulya Ekiz Kanik, Selim Ünlü   +5 more
doaj   +1 more source