Results 21 to 30 of about 834,721 (279)

The kinetics of folding of the NSH2 domain from p85 [PDF]

, 2019
SH2 domains are protein domains that mediate protein-protein interaction through the recognition and binding of specific sequences containing phosphorylated tyrosines.
Gianni, Stefano, Malagrinò, Francesca, Toto, Angelo, Visconti, Lorenzo   +3 more
core   +2 more sources

Utilizing the Combination of Binding Kinetics and Micro-Pharmacokinetics Link in Vitro α-Glucosidase Inhibition to in Vivo Target Occupancy

Biomolecules, 2019
Many compounds with good inhibitory activity (i.e., high affinity) within in vitro experiments failed in vivo studies due to a lack of efficacy from limited target occupancy (TO) in the drug discovery process.
Guopeng Wang, Yanhua Ji, Xueyan Li, Qian Wang, Hang Gong, Baoshun Wang, Yang Liu, Yanli Pan   +7 more
doaj   +1 more source

Integration of Power-Free and Self-Contained Microfluidic Chip with Fiber Optic Particle Plasmon Resonance Aptasensor for Rapid Detection of SARS-CoV-2 Nucleocapsid Protein

Biosensors, 2022
The global pandemic of COVID-19 has created an unrivalled need for sensitive and rapid point-of-care testing (POCT) methods for the detection of infectious viruses.
Ting-Chou Chang, Aileen Y. Sun, Yu-Chung Huang, Chih-Hui Wang, Shau-Chun Wang, Lai-Kwan Chau   +5 more
doaj   +1 more source

Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

mAbs, 2020
Based on their mechanism of action, two types of anti-CD20 antibodies are distinguished: Type I, which efficiently mediate complement-dependent cytotoxicity, and Type II, which instead are more efficient in inducing direct cell death.
Sina Bondza, Toine ten Broeke, Marika Nestor, Jeanette H. W. Leusen, Jos Buijs   +4 more
doaj   +1 more source

Enhanced Performance Electrochemical Biosensor for Detection of Prostate Cancer Biomarker PCA3 Using Specific Aptamer

Eng, 2023
In the quest for the development of accurate, reliable, and cost-effective biosensing technology for early diagnostics of prostate cancer, we describe here an electrochemical biosensor combining a simple transducing method of differential pulse ...
Sarra Takita, Alexei Nabok, Anna Lishchuk, Magdi H. Mussa, David Smith   +4 more
doaj   +1 more source

Foreword [PDF]

, 1942
Proteins that contain long disordered regions are prevalent in the proteome and frequently associated with diseases. However, the mechanisms by which such intrinsically disordered proteins (IDPs) recognize their targets are not well understood.
Dogan, Jakob, Engström, Åke, Jemth, Per, Mu, Xin, Schmidt, Tanja   +4 more
core   +2 more sources

Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events

Frontiers in Immunology, 2022
BackgroundIgG4 anbibodies are deficient in stability and may contribute to tumor-associated escape from immune surveillance. We developed an IgG1 backbone anti-programmed cell death protein-1 (PD-1) antibody, penpulimab, which is designed to remove ...
Zhaoliang Huang, Xinghua Pang, Tingting Zhong, Tailong Qu, Na Chen, Shun Ma, Xinrong He, Dennis Xia, Max Wang, Michelle Xia, Baiyong Li   +10 more
doaj   +1 more source

cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+ [PDF]

, 1985
cAMP induces a transient increase of cAMP and cGMP levels in Dictyostelium discoideum cells. Fast binding experiments reveal three types of cAMP-binding site (S, H and L), which have different off-rates (t0.5, 0.7-15 s) and different affinities (Kd, 15 ...
Brachet, Bumann, De Wit, Devreotes, Dinauer, Gerisch, Gerisch, Janssens, Juliani, Kay, Konijn, Leichtling, Marin, Mato, Pannbacker, Roos, Schaap, Shaffer, Stadel, Toews, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert, Van Haastert   +25 more
core   +3 more sources

Dynamic Docking: A Paradigm Shift in Computational Drug Discovery

Molecules, 2017
Molecular docking is the methodology of choice for studying in silico protein-ligand binding and for prioritizing compounds to discover new lead candidates.
Dario Gioia, Martina Bertazzo, Maurizio Recanatini, Matteo Masetti, Andrea Cavalli   +4 more
doaj   +1 more source

Binding kinetics of membrane-anchored receptors and ligands: molecular dynamics simulations and theory [PDF]

, 2015
The adhesion of biological membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. Central questions are how the binding kinetics of these proteins is affected by the membranes and by the membrane anchoring of the proteins.
Hu, Jinglei, Lipowsky, Reinhard, Weikl, Thomas R., Xu, Guang-Kui   +3 more
core   +2 more sources