Results 301 to 310 of about 3,018,689 (332)

Decreased protein binding and thiopental kinetics

Clinical Pharmacology and Therapeutics, 1982
Thiopental kinetics and protein binding were determined in seven surgical patients with chronic renal failure and a thiopental free fraction of 28.0 +/- 6.5% (SD) and in seven age- and weight-matched normal surgical patients with a thiopental free fraction of 15.7 +/- 2.4%. Thiopental clearance, based upon total plasma concentrations, rose from 3.2 +/-
P G, Burch, D R, Stanski
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Variables influencing cell binding assays for antibody binding kinetics

Nuclear Medicine Communications, 1993
Owing to growing interest in the use of cell binding assays for quality testing of radiolabelled antibodies in radioimmunoscintigraphy, factors in the assay which might affect final outcome were evaluated in order to accumulate information for effective and reliable assay design.
V, Boonkitticharoen, K, Laohathai
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Analyzing kinetic binding data

2004
Abstract A dissociation binding experiment measures the “off rate” for radioligand dissociating from the receptor. Initially ligand and receptor are allowed to bind, perhaps to equilibrium. At that point, you need to block further binding of radioligand to receptor so you can measure the rate of dissociation. There are several ways to do
Harvey Motulsky, Arthur Christopoulos
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Kinetics of Cooperative Binding

1979
Numerous models have been developed to describe cooperative phenomena in binding and enzyme systems. De Meyts has proposed a general model for cooperative binding in which the equilibrium constant of dissociation (K d ) is a linear function of receptor occupancy (De Meyts and Roth, 1975).
A. De Lean, D. Rodbard
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Kinetics of ligand binding to haemoproteins

Biochemical Society Transactions, 1990
A mass of experimental data has been accumulated in the 65 years since Hartridge and Roughton made the first measurement of the rapid reaction of haemoglobin with O2 in solution on a millisecond time scale, at first by flow-mixing methods, and, for 30 years or so, by flash photolysis.
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Molecular determinants of drug–receptor binding kinetics

Drug Discovery Today, 2013
It is increasingly appreciated that the rates at which drugs associate with and dissociate from receptors--the binding kinetics--directly impact drug efficacy and safety. The molecular determinants of drug-receptor binding kinetics remain poorly understood, however, especially when compared with the well-known factors that affect binding affinity.
Albert C, Pan, David W, Borhani, Ron O, Dror, David E, Shaw   +3 more
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Receptor-Binding Kinetics

1992
Abstract The first steps involved in receptor-ligand interactions are always second order binding reactions. They may, or may not, involve conformational changes of the receptor protein. The velocity of binding may be extremely rapid for neuroreceptors but can be much slower for hormone receptors.
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Kinetics of Nucleotide Binding to Pyruvate Carboxylase

Biochemistry, 1995
The kinetics of nucleotide binding to pyruvate carboxylase have been studied by measuring the fluorescence changes that occur on the binding and release of FTP and FDP, which are fluorescent formycin analogues of ATP and ADP. The rate constants and equilibrium binding constants for both MgFTP and MgFDP binding to pyruvate carboxylase have been ...
M A, Geeves, J P, Branson, P V, Attwood
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Kinetic studies of glutaraldehyde binding in liver

Biotechnic & Histochemistry, 2002
To study the kinetics of glutaraldehyde fixation, fresh rabbit liver cubes were immersed in 3% buffered 3H-glutaraldehyde for various periods of time. Following weighing and a brief rinse in water, the tissues were solubilized, and the radioactivity was measured in a scintillation counter. Binding of the isotope was half-maximal after approximately 4 h
K G, Helander, S, Widéhn, H F, Helander
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Binding Kinetics versus Affinities in BRD4 Inhibition

Journal of Chemical Information and Modeling, 2015
Bromodomains (BRDs) are protein modules that selectively recognize histones as a "reader" by binding to an acetylated lysine substrate. The human BRD4 has emerged as a promising drug target for a number of disease pathways, and several potent BRD inhibitors have been discovered experimentally recently.
Ming, Kuang, Jingwei, Zhou, Laiyou, Wang, Zhihong, Liu, Jiao, Guo, Ruibo, Wu   +5 more
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