Biomimetic Models to Investigate Membrane Biophysics Affecting Lipid–Protein Interaction
Frontiers in Bioengineering and Biotechnology, 2020 Biological membranes are highly dynamic in their ability to orchestrate vital mechanisms including cellular protection, organelle compartmentalization, cellular biomechanics, nutrient transport, molecular/enzymatic recognition, and membrane fusion ...
Joe Sarkis, Joe Sarkis, Véronique Vié
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An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics
Frontiers in Pharmacology, 2021 Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating.
Peter Lukacs +10 more
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Modeling the kinetics of hybridization in microarrays [PDF]
, 2007 Conventional fluorescent-based microarrays acquire data after the hybridization phase. In this phase the targets analytes (i.e., DNA fragments) bind to the capturing probes on the array and supposedly reach a steady state.
Hassibi, A. +3 more
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Complex Reaction Kinetics in Chemistry: A unified picture suggested by Mechanics in Physics [PDF]
, 2018 Complex biochemical pathways or regulatory enzyme kinetics can be reduced to chains of elementary reactions, which can be described in terms of chemical kinetics.
Agliari, Elena +4 more
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Probing Solid-Binding Peptide Self-Assembly Kinetics Using a Frequency Response Cooperativity Model
BiomimeticsBiomolecular adsorption has great significance in medical, environmental, and technological processes. Understanding adsorption equilibrium and binding kinetics is essential for advanced process implementation.
Taylor Bader +4 more
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Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation
Molecular Systems Biology, 2009 The insulin and insulin‐like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity.
Vladislav V Kiselyov +3 more
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Antibodies, 2019 Antibodies, antibody-like molecules, and therapeutics incorporating antibodies as a targeting moiety, such as antibody-drug conjugates, offer significant potential for the development of highly efficacious drugs against a wide range of disorders. Despite
Gareth D. Healey +4 more
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Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier
Journal of Structural Biology: X, 2023 The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy.
Kumar Tekwani Movellan +5 more
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Kinetics of binding and geometry of cells on molecular biochips
, 2011 We examine how the shape of cells and the geometry of experiment affect the reaction-diffusion kinetics at the binding between target and probe molecules on molecular biochips.
Argyrakis +22 more
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Collective behaviours: from biochemical kinetics to electronic circuits [PDF]
, 2013 In this work we aim to highlight a close analogy between cooperative behaviors in chemical kinetics and cybernetics; this is realized by using a common language for their description, that is mean-field statistical mechanics.
Agliari, Elena +4 more
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