Results 41 to 50 of about 3,018,689 (332)
Nature Communications, 2017 Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine.
Shicai Xu +10 more
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Ligand-receptor binding kinetics in drug design [PDF]
Biomeditsinskaya Khimiya, 2020 Traditionally, the thermodynamic values of affinity are considered as the main criterion for the development of new drugs. Usually, these values for drugs are measured in vitro at steady concentrations of the receptor and ligand, which are differed from in vivo environment.
D V, Borisov, A V, Veselovsky
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Purinergic Signalling Purinergic Signalling, 2019 There is a growing interest in understanding the binding kinetics of compounds that bind to G protein-coupled receptors prior to progressing a lead compound into clinical trials.
Mónica Bouzo-Lorenzo +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Long-distance transport of membrane-coated vesicles involves coordination of multiple motors such that at least one motor is bound to the microtubule at all times. Microtubule attachment of a membrane-bound motor comprises 2 steps: diffusing
Rui Jiang +5 more
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Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation
Molecular Systems Biology, 2009 The insulin and insulin‐like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity.
Vladislav V Kiselyov +3 more
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Antibodies, 2019 Antibodies, antibody-like molecules, and therapeutics incorporating antibodies as a targeting moiety, such as antibody-drug conjugates, offer significant potential for the development of highly efficacious drugs against a wide range of disorders. Despite
Gareth D. Healey +4 more
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Real-time tracking of drug binding to influenza A M2 reveals a high energy barrier
Journal of Structural Biology: X, 2023 The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy.
Kumar Tekwani Movellan +5 more
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Multi-scale modeling of drug binding kinetics to predict drug efficacy
Cellular and Molecular Life Sciences, 2019 Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration). Mathematical
F. Clarelli +4 more
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Kinetics of calcium binding to calbindin mutants [PDF]
European Journal of Biochemistry, 1988 The kinetics of calcium dissociation from wild‐type bovine calbindin D9k (the smallest protein known with a pair of EF‐hand calcium‐binding sites) and five mutants with single amino‐acid substitutions and/or deletions has been studied by stopped‐flow fluorescence methods, using the calcium chelator Quin 2.
S, Forsén +7 more
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Scientific Reports, 2019 Drug-target binding kinetics are suggested to be important parameters for the prediction of in vivo drug-efficacy. For G protein-coupled receptors (GPCRs), the binding kinetics of ligands are typically determined using association binding experiments in ...
R. Bosma +12 more
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