Results 51 to 60 of about 3,018,689 (332)

TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

Frontiers in Immunology
TRIM21 is a pivotal effector in the immune system, orchestrating antibody-mediated responses and modulating immune signaling. In this comprehensive study, we focus on the interaction of TRIM21 with Fc engineered antibodies and subsequent implications for
Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière   +9 more
doaj   +1 more source

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy

Frontiers in Immunology, 2022
Tumor-targeting antibody (Ab)-fused cytokines, referred to as immunocytokines, are designed to increase antitumor efficacy and reduce toxicity through the tumor-directed delivery of cytokines.
Keunok Jung, Sojung Yoo, Jung-Eun Kim, Wook Kim, Yong-Sung Kim, Yong-Sung Kim   +5 more
doaj   +1 more source

Quantifying Ligand-Protein Binding Kinetics with Self-Assembled Nano-Oscillators.

Analytical Chemistry, 2019
Measuring ligand-protein interactions is critical for unveiling molecular-scale biological processes in living systems and for screening drugs. Various detection technologies have been developed, but quantifying the binding kinetics of small molecule to ...
Guangzhong Ma, X. Shan, Shaopeng Wang, Yuyuan Tian   +3 more
semanticscholar   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Characterization of Binding of Magnetic Nanoparticles to Rolling Circle Amplification Products by Turn-On Magnetic Assay

Biosensors, 2019
The specific binding of oligonucleotide-tagged 100 nm magnetic nanoparticles (MNPs) to rolling circle products (RCPs) is investigated using our newly developed differential homogenous magnetic assay (DHMA).
Sobhan Sepehri, Björn Agnarsson, Teresa Zardán Gómez de la Torre, Justin F. Schneiderman, Jakob Blomgren, Aldo Jesorka, Christer Johansson, Mats Nilsson, Jan Albert, Maria Strømme, Dag Winkler, Alexei Kalaboukhov   +11 more
doaj   +1 more source

Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices.

Lab on a Chip, 2019
Microfluidic organ-on-chip devices constructed from polydimethylsiloxane (PDMS) have proven useful in studying both beneficial and adverse effects of drugs, supplements, and potential toxicants.
Alexander W. Auner, K. Tasneem, D. Markov, L. Mccawley, M., Shane Hutson   +5 more
semanticscholar   +1 more source

Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics

eLife, 2021
The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells.
Michael I. Barton, Stuart A. MacGowan, Mikhail A. Kutuzov, Omer Dushek, G. Barton, P. A. van der Merwe   +5 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Probing Solid-Binding Peptide Self-Assembly Kinetics Using a Frequency Response Cooperativity Model

Biomimetics
Biomolecular adsorption has great significance in medical, environmental, and technological processes. Understanding adsorption equilibrium and binding kinetics is essential for advanced process implementation.
Taylor Bader, Kyle Boone, Chris Johnson, Cindy L. Berrie, Candan Tamerler   +4 more
doaj   +1 more source