Results 61 to 70 of about 834,721 (279)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Improved intratumoral penetration of IL12 immunocytokine enhances the antitumor efficacy

Frontiers in Immunology, 2022
Tumor-targeting antibody (Ab)-fused cytokines, referred to as immunocytokines, are designed to increase antitumor efficacy and reduce toxicity through the tumor-directed delivery of cytokines.
Keunok Jung, Sojung Yoo, Jung-Eun Kim, Wook Kim, Yong-Sung Kim, Yong-Sung Kim   +5 more
doaj   +1 more source

Complete integrability of information processing by biochemical reactions [PDF]

, 2016
Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kinetics, (anti-)
Agliari, Elena, Barra, Adriano, Moro, Antonio, Schiavo, Lorenzo Dello   +3 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Rapid and Label-Free Analysis of Antigen–Antibody Dynamic Binding of Tumor Markers Using Piezoelectric Quartz Crystal Biosensor

Biosensors, 2023
Quantitative biomacromolecular diagnosis is rapidly developing in molecular oncology. In this study, we developed a continuous flow immunoassay device based on a piezoelectric (PZ) quartz crystal biosensor fabricated with whole-electrode occupation for ...
Yan Chen, Huashan Shi
doaj   +1 more source

Multiplexed Affinity Measurements of Extracellular Vesicles Binding Kinetics [PDF]

, 2021
Elisa Chiodi, George G. Daaboul, Allison M. Marn, M. Selim Ünlü   +3 more
openalex   +1 more source

First Passage and Cooperativity of Queuing Kinetics

, 2005
We model the kinetics of ligand-receptor systems, where multiple ligands may bind and unbind to the receptor, either randomly or in a specific order.
C. Doering, C. J. Thompson, C. W. Gardiner, D. Clarke, D. Gross, Maria R. D’Orsogna, N. Alberding, N. G. Van Kampen, N. J. Eungdamrong, P. W. Nelson, R. E. Weber, S. Kulin, S. Redner, Tom Chou, X. Ma   +14 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Identification, Screening, and Comprehensive Evaluation of Novel DPP-IV Inhibitory Peptides from the Tilapia Skin Gelatin Hydrolysate Produced Using Ginger Protease

Biomolecules, 2022
Purpose: Inhibition of dipeptidyl peptidase-IV (DPP-IV) is an effective therapy for treating type II diabetes (T2D) that has been widely applied in clinical practice.
Wei Liu, Xinyu Wang, Wenning Yang, Xueyan Li, Dongying Qi, Hongjiao Chen, Huining Liu, Shuang Yu, Yanli Pan, Yang Liu, Guopeng Wang   +10 more
doaj   +1 more source

Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics [PDF]

, 2021
Michael I. Barton, Stuart A. MacGowan, Mikhail A. Kutuzov, Omer Dushek, Geoffrey J. Barton, P. Anton van der Merwe   +5 more
openalex   +1 more source