Results 321 to 330 of about 8,730,538 (402)

DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site. [PDF]

iScience
Frey AF, Schwan M, Weldert AC, Kadenbach V, Kopp J, Nidoieva Z, Zimmermann RA, Gleue L, Zimmer C, Jörg M, Friedland K, Helm M, Sinning I, Barthels F.   +13 more
europepmc   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Diagnostic Utility of Testing for Novel Murine Autoantibodies for Sjögren's Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, Accepted Article.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren's disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis. [PDF]

PLoS Pathog
Joseph A, Cheng X, Harding J, Al-Saleem J, Green P, Griffith M, Veis D, Rauch DA, Ratner L.   +8 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Studies of the membrane-bound flavocytochrome MsrQ flavin mononucleotide (FMN)-binding site reveal an unexpected ubiquinone cofactor. [PDF]

FEBS J
Carpentier P, Pierrel F, Duraffourg N, Guigliarelli B, Hajj Chehade M, Flandrin L, Basset C, Caux C, Torelli S, Nivière V.   +9 more
europepmc   +1 more source

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin. [PDF]

EMBO J
Zhou X, Chen H, Peng S, Si Y, Wang G, Yang L, Zhou Q, Lu M, Xie Q, He X, Wu M, Xiao X, Luo X, Feng X, Wang W, Luo S, Li Y, Qin J, Chen M, Zhang Q, Hu W, Liang S, Hou T, Liu Z.   +23 more
europepmc   +1 more source

Benchmarking transcription factor binding site prediction models: a comparative analysis on synthetic and biological data. [PDF]

Brief Bioinform
Tognon M, Kumbara A, Betti A, Ruggeri L, Giugno R.   +4 more
europepmc   +1 more source

The PP2A-B56 Binding Site LxxIxE Contributes to Asp-Mediated Spindle Pole Stability. [PDF]

Cytoskeleton (Hoboken)
Quiniou M, Burns MC, McDermott A, Jaworek K, Scott SJ, Wakefield JG, Borgal L.   +6 more
europepmc   +1 more source