Results 301 to 310 of about 8,224,245 (384)

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Disrupting ZBTB7A or BCL11A binding sites reactivates fetal hemoglobin in erythroblasts from healthy and β⁰-thalassemia/HbE individuals. [PDF]

Sci Rep
Wongborisuth C, Innachai P, Saisawang C, Tubsuwan A, Jearawiriyapaisarn N, Kaewprommal P, Piriyapongsa J, Chiangjong W, Anurathapan U, Songdej D, Tangprasittipap A, Hongeng S.   +11 more
europepmc   +1 more source

Aminoacyl-tRNA binding at the recognition site is the first step of the elongation cycle of protein synthesis.

, 1977
James A. Lake
openalex   +1 more source

Double‐Stranded DNA Reduces dsRNA Degradation in the Saliva and Significantly Enhanced RNAi‐Mediated Gene Silencing in Halyomorpha halys

Advanced Biology, EarlyView.
The invasive pest Halyomorpha halys causes significant crop losses requiring innovative pest control strategies such as RNA interference (RNAi). However, oral RNAi is largely ineffective in H. halys. This study shows that double‐stranded DNA (dsDNA) stabilizes dsRNA in saliva by inhibiting a highly expressed nuclease.
Venkata Partha Sarathi Amineni, Georg Petschenka, Aline Koch   +2 more
wiley   +1 more source

Multiple LPA₃ Receptor Agonist Binding Sites Evidenced Under Docking and Functional Studies. [PDF]

Int J Mol Sci
Solís KH, Romero-Ávila MT, Rincón-Heredia R, Romero-Romero S, Correa-Basurto J, García-Sáinz JA.   +5 more
europepmc   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Exploring the Multiligand Binding Specificity of Saposin B Reveals Two Binding Sites

ACS Omega, 2017
Jay Tinklepaugh, Britannia M. Smith, Etta Hanlon, Chloe Zubieta, Fadi Bou-Abdallah, Robert P. Doyle   +5 more
doaj   +1 more source

Predicting CTCF cell type active binding sites in human genome. [PDF]

Sci Rep
Chai L, Gao J, Li Z, Sun H, Liu J, Wang Y, Zhang L.   +6 more
europepmc   +1 more source

Properties and Specificity of Binding Sites for 125I-Nerve Growth Factor in Embryonic Heart and Brain

, 1974
William A. Frazier, Linda F. Boyd, Morris W. Pulliam, Andrzej Szutowicz, Ralph Bradshaw   +4 more
openalex   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source