Results 311 to 320 of about 2,663,361 (333)
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Database Searches for Binding Sites
Science, 2000In their Report “Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons” (7 Apr., p. [136][1]), G. G. Loots and colleagues identify conserved noncoding sequences (CNSs) in orthologous regions of the interleukin (IL)-4/13/5 locus of ...
K, Murphy +3 more
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Peripheral benzodiazepine binding sites
Pharmacology & Therapeutics, 1989Article de synthese sur les sites de fixation peripheriques des benzodiazepines: distribution, fixation biologique, action au niveau du systeme nerveux central, regulation par le GABA et le stress, regulation endocrine, relation avec les canaux calcium, autres ligands, role ...
V, Saano, L, Rägo, M, Räty
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Substrate-binding sites in acetylcholinesterase
Trends in Pharmacological Sciences, 1991Acetylcholinesterase is among the most efficient enzymes known. In order to provide an explanation for its catalytic and regulatory mechanisms, including the high turnover rate, the specific amino acid residues involved in substrate binding and hydrolysis need to be identified.
F, Hucho, J, Järv, C, Weise
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Hormone binding site of corticosteroid binding globulin
Nature Structural & Molecular Biology, 1995A new location for the hormone-binding site of corticosteroid binding globulin is propose based on experimental data, together with a sequence and structural alignment of the serpin ...
P, Edgar, P, Stein
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Binding sites for calcium on tubulin
Biochemistry, 1977Calcium ions can inhibit the in vitro assembly of microtubules and, therefore, may play a role in the regulation of microtubule formation in vivo. In order to test the validity of this hypothesis; the interaction between calcium and pruified brain microtubular protein has been investigated by standard binding assays.
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The taxonomy of binding sites in proteins
Molecular and Cellular Biochemistry, 1978Conservation of polypeptide fold and mode of ligand binding is frequently found within proteins of related function. Examples illustrating this phenomenon are taken from NAD linked enzymes, nucleotide binding proteins, polysaccharide binding proteins, heme binding proteins and enzymes with essential Fe--S complexes or zinc atoms.
M G, Rossmann, P, Argos
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Hydrophobic binding site in acetylcholinesterase
Journal of Medicinal Chemistry, 1975The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA).
George M. Steinberg +4 more
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A citrate-binding site in calmodulin
Journal of Molecular Recognition, 1998Calmodulin (CaM) is a major Ca2+ messenger which, upon Ca2+ activation, binds and activates a number of target enzymes involved in crucial cellular processes. The dependence on Ca2+ ion concentration suggests that CaM activation may be modulated by low-affinity Ca2+ chelators.
T, Neufeld +3 more
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Localization of the Chaperone Binding-Site
Biochemical and Biophysical Research Communications, 1993The hypothesis derived from models of the multi-oligomeric chaperone complex suggests that partially denatured proteins bind in a central cavity in the aggregate. To test this hypothesis, the molecular chaperone, alpha crystallin, was bound to partially denatured forms of gamma crystallin, and the binding site was visualized by immunogold localization.
D, Boyle, S, Gopalakrishnan, L, Takemoto
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Ligand Binding With Continuous Modification of Binding Sites
Journal of Biomolecular Structure and Dynamics, 2004Simultaneous formulation binding and structure modification of the binding site leads to binding process that can be analyzed within the framework of the non-linear theory of dynamic systems. Such an approach allows us to obtain several properties of the binding center: plurality of stationary (stable and unstable) states at binding, recognition of ...
V B, Arakelyan +4 more
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