Results 311 to 320 of about 8,224,245 (384)

Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity. [PDF]

Biol Res
Raiqueo F, Amigo R, Gutiérrez JL.
europepmc   +1 more source

Optimized Cell‐Based Platform for Platelet‐Free Detection of Heparin‐Induced Thrombocytopenia Antibodies

Advanced Biology, EarlyView.
This study optimized a cell‐based ELISA for HIT antibody detection using PF4‐coated breast cancer cells (MDA‐MB‐231). Enhanced binding was observed at 50 mM NaCl and 4% paraformaldehyde fixation. Live MDA‐MB‐231 and HCT‐116 cells demontrated superior sensitivity and specificity, providing a promising platelet‐free alternative for clinical HIT diagnosis.
Li‐Yu Chen, Uwe Schirmer, Peter F. Zipfel, Doris Heinrich, Thi‐Huong Nguyen   +4 more
wiley   +1 more source

Three classes of propofol binding sites on GABA_A receptors. [PDF]

J Biol Chem
Chen ZW, Chintala SM, Bracamontes J, Sugasawa Y, Pierce SR, Varga BR, Smith EH, Edge CJ, Franks NP, Cheng WWL, Akk G, Evers AS.   +11 more
europepmc   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Modeling and Molecular Dynamics Studies of Flavone-DENV E-3 Protein-SWCNT Interaction at the Flavonoid Binding Sites. [PDF]

Viruses
Espíndola C.
europepmc   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection. [PDF]

Nat Commun
Alcorn MDH, Sun C, Gilliland TC, Lukash T, Crasto CM, Raju S, Diamond MS, Weaver SC, Klimstra WB.   +8 more
europepmc   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Protocol for identifying genomic binding sites of mitotic bookmarkers in Drosophila neural stem cells and cultured mammalian cells. [PDF]

STAR Protoc
Shen Y, Liu J, Song Y.
europepmc   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source