Results 321 to 330 of about 8,324,980 (383)

iProtDNA-SMOTE: Enhancing protein-DNA binding sites prediction through imbalanced graph neural networks. [PDF]

PLoS One
Huang R, Qiu W, Xiao X, Lin W.
europepmc   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells. [PDF]

Elife
Oqua AI, Chao K, El Eid L, Casteller L, Baxter BP, Miguéns-Gómez A, Barg S, Jones B, Bernardino de la Serna J, Rouse SL, Tomas A.   +10 more
europepmc   +1 more source

RRP9 Promotes Esophageal Squamous Cell Carcinoma Progression through E2F1 Transcriptional Regulation of CDK1

Advanced Biology, EarlyView.
The study reveals that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis in patients. Furthermore, it is found that RRP9 promotes ESCC progression through enhancing the E2F1‐mediated transcriptional regulation of CDK1.
Gang He, Yilong Wan, Yanbo Zhu, Bo Peng, Shengxiang Shao, Xinyi Zou, Zhenyu Han, Jiaxi Li, Sheng Ju, Xin Tong, Jun Zhao, Hansi Liang, Liuqing Zhang, Jiashi Xiong, Dong Jiang   +14 more
wiley   +1 more source

Tissue-Specific Chromatin Accessibility Regions and Transcription Factor Binding Sites in Pig Brain and Endocrine Tissues. [PDF]

Mol Neurobiol
Ponsuksili S, Hadlich F, Trakooljul N, Li S, Reyer H, Oster M, Wimmers K.   +6 more
europepmc   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

The binding sites of carbon dioxide, nitrous oxide, and xenon reveal a putative exhaust channel for bovine cytochrome c oxidase. [PDF]

J Biol Chem
Muramoto K, Ide T, Shinzawa-Itoh K.
europepmc   +1 more source

Three classes of propofol binding sites on GABA_A receptors. [PDF]

J Biol Chem
Chen ZW, Chintala SM, Bracamontes J, Sugasawa Y, Pierce SR, Varga BR, Smith EH, Edge CJ, Franks NP, Cheng WWL, Akk G, Evers AS.   +11 more
europepmc   +1 more source

Predicting CTCF cell type active binding sites in human genome. [PDF]

Sci Rep
Chai L, Gao J, Li Z, Sun H, Liu J, Wang Y, Zhang L.   +6 more
europepmc   +1 more source

Multiple LPA₃ Receptor Agonist Binding Sites Evidenced Under Docking and Functional Studies. [PDF]

Int J Mol Sci
Solís KH, Romero-Ávila MT, Rincón-Heredia R, Romero-Romero S, Correa-Basurto J, García-Sáinz JA.   +5 more
europepmc   +1 more source