Results 341 to 350 of about 8,224,245 (384)
Some of the next articles are maybe not open access.
1996
This chapter assesses advances in the understanding and manipulation of antibody binding sites and variable regions. The antigen binding region of an antibody reduced to a 25-kDa minimum comprises of a noncovalent heterodimer of V H and V L domains.
Edgar Haber +2 more
openaire +3 more sources
This chapter assesses advances in the understanding and manipulation of antibody binding sites and variable regions. The antigen binding region of an antibody reduced to a 25-kDa minimum comprises of a noncovalent heterodimer of V H and V L domains.
Edgar Haber +2 more
openaire +3 more sources
Current Opinion in Biotechnology, 1992
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
Elizabeth D. Getzoff +2 more
openaire +2 more sources
Metal ions have a role in a variety of important functions in proteins including protein folding, assembly, stability, conformational change, and catalysis. The presence or absence of a given metal ion is crucial to the conformation or activity of over one third of all proteins.
Elizabeth D. Getzoff +2 more
openaire +2 more sources
What makes a binding site a binding site?
Current Opinion in Structural Biology, 1995Organic probe molecules have recently been used to define hydrophobic binding sites on the surface of proteins. It appears that the presence of water on the surface of a protein plays a crucial role in the interaction between that protein and its binding site.
openaire +3 more sources
Benzodiazepine-Binding Site and Gaba-Binding Site
1983There is a body of experimental evidence to suggest that the benzodiazepine-binding site, the GABA-binding site and the chloride ionophore are functionally correlated. To elucidate this issue, the interactions among these components in both membrane-bound state and soluble state are examined.
Eric A. Barnard, Li-Ren Chang
openaire +2 more sources
Binding Sites for Ethylene [PDF]
, 1984 This article describes recent work on the characterisation and purification of an ethylene binding site complex (EBS) derived from developing cotyledons of Phaseolus vulgaris L.
C. J. R. Thomas +3 more
openaire +1 more source
Journal of Neurochemistry, 1988
Abstract: The distribution and characterization of specific melatonin binding sites were studied using 125I‐melatonin. Autoradiography revealed only three sites of specific melatonin binding in brain: the suprachiasmatic nuclei, the median eminence, and the small part of choroid plexus at the caudal end of the fourth ventricle.
openaire +3 more sources
Abstract: The distribution and characterization of specific melatonin binding sites were studied using 125I‐melatonin. Autoradiography revealed only three sites of specific melatonin binding in brain: the suprachiasmatic nuclei, the median eminence, and the small part of choroid plexus at the caudal end of the fourth ventricle.
openaire +3 more sources
The binding site for C1q on IgG [PDF]
Nature, 1988 In humoral defence, pathogens are cleared by antibodies acting as adaptor molecules: they bind to antigen and trigger clearance mechanisms such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and complement lysis. The first step in the complement cascade is the binding of C1q to the antibody.
Alexander R. Duncan, Greg Winter
openaire +2 more sources
Mitochondrial Binding Sites for Triiodothyronine
Endocrinology, 1978Metabolic effects upon rat liver mitochondria have been observed by others within 2 min of injection of massive amounts of L-T4. Reported here is the subcellular distribution of 2--5 ng high specific activity [125I]L-T3 2 min after ip injection with and without a loading dose of 30 micrograms unlabeled T3.
Roger L. Greif, Denise A. Sloane
openaire +3 more sources
On the receptor binding site of relaxins
International Journal of Peptide and Protein Research, 1988Relaxin plays a critical role in viviparity and has recently been implicated as a hormone of oviparity as well. In most mammals relaxin causes the widening of the birth canal during parturition and suppresses uterine motility during pregnancy. Relaxins isolated from several species have shown a great deal of sequence variability, and speculations ...
Christian Schwabe, Erika E. Büllesbach
openaire +3 more sources
A Binding Site for Chlorambucil on Metallothionein
Biochemistry, 1996It is of interest to test the hypothesis that induced metallothionein (MT) acts in acquired drug resistance by covalent sequestration. In this study MT was incubated in vitro with chlorambucil (CHB) under conditions where only 1:1 covalent adducts were formed.
Joseph Zaia +6 more
openaire +3 more sources