Results 81 to 90 of about 99,718 (252)
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
Metsanduslikud Uurimused, 2017 The Net Present Value (NPV) approach is widely applied to assess forest investments, but this method has serious shortcomings, which we propose to overcome by switching to the assessment through the Real Options Approach (ROA).
Broz Diego +4 more
doaj +1 more source
The Meaning of Binomial Distribution [PDF]
Nature, 1960 Two generalizations of the simple binomial distribution are common in statistical text-books, one due to W. Lexis and the other to S. D. Poisson. Lexis considered the case in which the probability of an event occurring, p, is constant in the N trials of one experiment, but varies among several such experiments.
openaire +2 more sources
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction
Advanced Science, EarlyView.Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li +3 more
wiley +1 more source
The Chernoff Modification of the Fisher Exact Test for the Difference of Two Binomial Probabilities [PDF]
To test the difference of two binomial probabilities, we will apply the Fisher exact test modified by Chernoff (2002), which will be called CMF test. The key idea is to use the P-value of Fisher exact test as a test statistic and this makes it possible ...
Takahashi, Hajime, Uematsu, Kazuki
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Advanced Science, EarlyView.Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao +20 more
wiley +1 more source
Characterizations of Continuous Binomial and Negative Binomial Mixtures
Biometrical Journal, 1984 AbstractCharacterizations are given for binomial (n, ϑ) and negative binomial (k, ϑ) mixtures in terms of the regression function of the mixing random variableYon the mixture variableX.In both casesYis the parameter ϑ and the mixing distribution is a continuous distribution on (0, 1) and on (0, ∞) respectively. Biological applications are indicated.
openaire +3 more sources
Random Dynamics and Finance: Constructing Implied Binomial Trees from a Predetermined Stationary Den [PDF]
We introduce a general binomial model for asset prices based on the concept of random maps. The asymptotic stationary distribution for such model is studied using techniques from dynamical systems.
Silvia Mayoral +3 more
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