Results 51 to 60 of about 44,005 (262)

Binomial Number System

Applied Sciences, 2021
This paper presents and first scientifically substantiates the generalized theory of binomial number systems (BNS) and the method of their formation for reliable digital signal processing (DSP), transmission, and data storage.
Oleksiy Borysenko, Svitlana Matsenko, Vjaceslavs Bobrovs   +2 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Three new classes of binomial Fibonacci sums [PDF]

Transactions on Combinatorics
In this paper, we introduce three new classes of binomial sums involving Fibonacci (Lucas) numbers and weighted binomial coefficients. One particular result is linked to a problem proposal recently published in the journal The Fibonacci Quarterly.
Robert Frontczak
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

Applications of Lehmer’s Infinite Series Involving Reciprocals of the Central Binomial Coefficients

Journal of Function Spaces, 2022
The main objective of this paper is to establish several new closed-form evaluations of the generalized hypergeometric function Fq+1qz for q=2,3,4,5. This is achieved by means of separating the generalized hypergeometric function Fq+1qz (q=2,3,4,5) into ...
B. R. Srivatsa Kumar, Adem Kılıçman, Arjun K. Rathie   +2 more
doaj   +1 more source

A Note on Extended Binomial Coefficients

J. Integer Seq., 2014
We study the distribution of the extended binomial coefficients by deriving a complete asymptotic expansion with uniform error terms. We obtain the expansion from a local central limit theorem and we state all coefficients explicitly as sums of Hermite polynomials and Bernoulli numbers.
openaire   +6 more sources

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Some divisibility properties of binomial and q -binomial coefficients

Journal of Number Theory, 2014
We first prove that if $a$ has a prime factor not dividing $b$ then there are infinitely many positive integers $n$ such that $\binom {an+bn} {an}$ is not divisible by $bn+1$. This confirms a recent conjecture of Z.-W. Sun. Moreover, we provide some new divisibility properties of binomial coefficients: for example, we prove that $\binom {12n} {3n}$ and
Krattenthaler, Christian, Guo, Victor J. W.   +1 more
openaire   +4 more sources

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source