Results 71 to 80 of about 4,667,206 (256)

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

On the Conflation of Negative Binomial and Logarithmic Distributions

Axioms
In recent decades, the study of discrete distributions has received increasing attention in the field of statistics, mainly because discrete distributions can model a wide range of count data.
Anfal A. Alqefari, Abdulhamid A. Alzaid, Najla Qarmalah   +2 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Option Implied Risk-Neutral Distributions and Implied Binomial Trees: A Literature Review [PDF]

In this selective literature review, we start by observing that in efficient markets, there is information incorporated in option prices that might help us to design option pricing models.
Jackwerth, Jens Carsten
core  

Characterizations of multinomial distributions based on conditional distributions

International Journal of Mathematics and Mathematical Sciences, 1996
Several characterizations of the joint multinomial distribution of two discrete random vectors are derived assuming conditional multinomial distributions.
Khoan T. Dinh, Truc T. Nguyen, Yining Wang   +2 more
doaj   +1 more source

Ductile B2 Intermetallics‐Driven Strength‐Ductility Synergy in Heterolaminated Multi‐Principal Element Alloys

Advanced Science, EarlyView.
Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang, Feilong Jiang, Qiming Zhuang, Dingshan Liang, Jiasi Luo, Kangjie Chu, Junhua Luan, Zengbao Jiao, Robert O. Ritchie, Fuzeng Ren   +9 more
wiley   +1 more source

On the Logic of a Prior Based Statistical Mechanics of Polydisperse Systems: The Case of Binary Mixtures

Entropy, 2019
Most undergraduate students who have followed a thermodynamics course would have been asked to evaluate the volume occupied by one mole of air under standard conditions of pressure and temperature. However, what is this task exactly referring to?
Fabien Paillusson
doaj   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

Using the negative binomial distribution to investigate sports attendance [PDF]

, 2008
Most of the research into sports attendance uses cognitive and hedonic models as the theoretical foundation. While these models are useful at explaining attendance variance, they are not good predictors of attendance.
Neale, Larry, Funk, Daniel
core  

A generalization of the negative binomial distribution

Journal of Biostatistics and Epidemiology, 2017
Background & Aim: Consider a sequence of independent Bernoulli trials with p denoting the probability of success at each trial. With this definition, the probability that the nth success proceed by r failures follows the negative binomial distribution ...
Maryam Nazemipour, Mahmood Mahmoudi
doaj