Results 81 to 90 of about 13,727 (246)

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

On the accuracy of the binomial approximation to the distance distribution of codes

, 1995
The binomial distribution is a well-known approximation to the distance spectra of many classes of codes.
Krasikov, I, Litsyn, S
core   +1 more source

Approximation of binomial probability function for a normal probability function

, 2011
Notions of statistics and probabilityThe digital animation presents the approximation of the function of the binomial probability for a function of normal probability, also known as Gaussian distribution.
Rojo, Isabel Martín, Lopez, Miguel Angel de la Fuente, Pujato, Carmen Candioti Lopez, Barrio, Manuel Gertrudix   +3 more
core   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Empirical-distribution-function tests for the beta-binomial model

, 2010
碩士本文主要是探討應用經驗分布函數對貝他-二項式模式做適合度檢定. 我們提出兩種以經驗分布函數為基礎之統計量的檢定方法, 然後透過蒙地卡羅模擬研究去檢定統計量在對立假設下之不同分布的經驗檢定力. 與 Garren et al. (2001) 的方法相比較, 我們的方法在大多數的情況下是具有較大檢定力的.
周正杰; Chou, Cheng-chieh
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Using the negative binomial distribution to investigate sports attendance

, 2008
Most of the research into sports attendance uses cognitive and hedonic models as the theoretical foundation. While these models are useful at explaining attendance variance, they are not good predictors of attendance.
Neale, Larry, Funk, Daniel
core  

Approximation of binomial probability function for a normal probability function

, 2016
Educação Superior::Ciências Exatas e da Terra::MatemáticaThe digital animation presents the approximation of the function of the binomial probability for a function of normal probability, also known as Gaussian distribution.
Rojo, Isabel Martín, Lopez, Miguel Angel de la Fuente, Pujato, Carmen Candioti Lopez, Barrio, Manuel Gertrudix   +3 more
core   +1 more source