Results 81 to 90 of about 389,511 (337)

Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis

Advanced Science, EarlyView.
This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu, Xuyu Zhao, Zixin Chen, Jingying Huang, Tengteng Dai, Jianxin Zhou, Luyao Xiao, Luonan Chen, Robert Chunhua Zhao, Jiao Wang   +9 more
wiley   +1 more source

Generalized distributions of order k associated with success runs in Bernoulli trials

International Journal of Mathematics and Mathematical Sciences, 2003
In a sequence of independent Bernoulli trials, by counting multidimensional lattice paths in order to compute the probability of a first-passage event, we derive and study a generalized negative binomial distribution of order k, type I, which extends to ...
Gregory A. Tripsiannis, Afroditi A. Papathanasiou, Andreas N. Philippou   +2 more
doaj   +1 more source

Multi‐Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend

Advanced Science, EarlyView.
The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He, Jian Xiao, Xiaoqiang Shen, Kankan Zhao, Xiaoyu Lei, Huarui Zhang, Chao Sun, Huijie Lu, Yongqi Shao   +8 more
wiley   +1 more source

The zero inflated negative binomial – Crack distribution: some properties and parameter estimation [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
The zero inflated negative binomial-Crack (ZINB-CR) distribution is a mixture of Bernoulli distribution and negative binomial-Crack (NB-CR) distribution, which is an alternative distribution for the excessive zero counts and overdispersion.
Pornpop Saengthong, Winai Bodhisuwan, Ampai Thongteeraparp   +2 more
doaj  

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Mathematical Properties of the Binomial-Poisson Distribution

Journal of Applied Sciences and Environmental Management
This study conducts a thorough analytical exploration of the Binomial-Poisson distribution, a compound probability model where the number of Binomial trials follows a Poisson distribution. Through application of the compound distribution methodology and
A. A. Ayenigba, D. A. Afariogun, O. M. Ajao, I. K. Adebayo   +3 more
doaj   +4 more sources

Approximation of binomial distribution [PDF]

, 2018
Cílem této práce je přinést nějaké znalosti o aproximaci binomického rozdělení. V první části studujeme elementární vlastnosti některých známých distribucí. Druhá část je věnována problematice odhadů minimálního počtu experimentů, založených na binomické
Vronka, David
core  

Moody's Correlated Binomial Default Distributions for Inhomogeneous Portfolios

, 2006
This paper generalizes Moody's correlated binomial default distribution for homogeneous (exchangeable) credit portfolio, which is introduced by Witt, to the case of inhomogeneous portfolios. As inhomogeneous portfolios, we consider two cases.
Andersen L, Cifuettes A, Duffie D, Fabozzi FJ, Finger CC, Finger CC, Frey R, Hull J, Hull J, Hull J, Jobst NJ, K. Kitsukawa, Laurent J-P, M. Hisakado, Martin R, Molins J, S. Mori, Schönbucher P, Schönbucher P, Vasicek O, Witt G   +20 more
core   +3 more sources

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source