Results 101 to 110 of about 17,288,534 (269)

Bio-Medical Library Bulletin, No. 89 (1986-02)

, 1986
Bio-Medical Library. (1986). Bio-Medical Library Bulletin, No. 89 (1986-02).
Bio-Medical Library
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Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 07 (1969-05)

, 1969
Bio-Medical Library. (1969). Bio-Medical Library Bulletin, No. 07 (1969-05).
Bio-Medical Library
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 28 (1972-12)

, 1972
Bio-Medical Library. (1972). Bio-Medical Library Bulletin, No. 28 (1972-12).
Bio-Medical Library
core  

The Bio-Economy Concept and Knowledge Base in a Public Goods and Farmer Perspective

, 2012
Currently an industrial perspective dominates the EU policy framework for a European bio-economy. The Commission’s proposal on the bio-economy emphasises greater resource-efficiency, largely within an industrial perspective on global economic ...
Padel, Susanne, Levidov, Les, Susanne Padel, Schmidt, Otto; Università di Bologna, Otto Schmidt, Levidow, Les, Schmid, Otto, Les Levidow   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 77 (1983-02)

, 1983
Bio-Medical Library. (1983). Bio-Medical Library Bulletin, No. 77 (1983-02).
Bio-Medical Library
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 53 (1977-09)

, 1977
Bio-Medical Library. (1977). Bio-Medical Library Bulletin, No. 53 (1977-09).
Bio-Medical Library
core