Results 81 to 90 of about 17,288,534 (269)

Bio-Medical Library Bulletin, No. 51 (1977-04)

, 1977
Bio-Medical Library. (1977). Bio-Medical Library Bulletin, No. 51 (1977-04).
Bio-Medical Library
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Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 100 (1989-04)

, 1989
Bio-Medical Library. (1989). Bio-Medical Library Bulletin, No. 100 (1989-04).
Bio-Medical Library
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Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 54 (1977-12)

, 1977
Bio-Medical Library. (1977). Bio-Medical Library Bulletin, No. 54 (1977-12).
Bio-Medical Library
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Bio-Medical Library Bulletin, No. 19 (1971-03)

, 1971
Bio-Medical Library. (1971). Bio-Medical Library Bulletin, No. 19 (1971-03).
Bio-Medical Library
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Engineering transverse cell deformation of bamboo by controlling localized moisture content

Nature Communications
Bamboo’s native structure, defined by the vertical growth pattern of its vascular bundles and parenchyma cell tissue, limits its application in advanced engineering materials.
Tian Bai, Jie Yan, Jiqing Lu, Jie Zhou, Hang Yao, Xiuwen He, Shaohua Gu, Zhihan Tong, Sheldon Q. Shi, Jian Li, Wanli Cheng, Dong Wang, Guangping Han, Chaoji Chen   +13 more
doaj   +1 more source

Bio-Medical Library Bulletin, No. 99 (1988-11)

, 1988
Bio-Medical Library. (1988). Bio-Medical Library Bulletin, No. 99 (1988-11).
Bio-Medical Library
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